| http://purl.uniprot.org/citations/27234056 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27234056 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitochondrial respiration is regulated in CD8(+) T cells during the transition from naive to effector and memory cells, but mechanisms controlling this process have not been defined. Here we show that MCJ (methylation-controlled J protein) acted as an endogenous break for mitochondrial respiration in CD8(+) T cells by interfering with the formation of electron transport chain respiratory supercomplexes. Metabolic profiling revealed enhanced mitochondrial metabolism in MCJ-deficient CD8(+) T cells. Increased oxidative phosphorylation and subcellular ATP accumulation caused by MCJ deficiency selectively increased the secretion, but not expression, of interferon-γ. MCJ also adapted effector CD8(+) T cell metabolism during the contraction phase. Consequently, memory CD8(+) T cells lacking MCJ provided superior protection against influenza virus infection. Thus, MCJ offers a mechanism for fine-tuning CD8(+) T cell mitochondrial metabolism as an alternative to modulating mitochondrial mass, an energetically expensive process. MCJ could be a therapeutic target to enhance CD8(+) T cell responses."xsd:string |
| http://purl.uniprot.org/citations/27234056 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2016.02.018"xsd:string |
| http://purl.uniprot.org/citations/27234056 | http://purl.uniprot.org/core/author | "Yang R."xsd:string |
| http://purl.uniprot.org/citations/27234056 | http://purl.uniprot.org/core/author | "Anguita J."xsd:string |
| http://purl.uniprot.org/citations/27234056 | http://purl.uniprot.org/core/author | "Haynes L."xsd:string |
| http://purl.uniprot.org/citations/27234056 | http://purl.uniprot.org/core/author | "D'Alessandro A."xsd:string |
| http://purl.uniprot.org/citations/27234056 | http://purl.uniprot.org/core/author | "Hansen K.C."xsd:string |
| http://purl.uniprot.org/citations/27234056 | http://purl.uniprot.org/core/author | "Thornton T.M."xsd:string |
| http://purl.uniprot.org/citations/27234056 | http://purl.uniprot.org/core/author | "Jun Y.W."xsd:string |
| http://purl.uniprot.org/citations/27234056 | http://purl.uniprot.org/core/author | "Hatle K.M."xsd:string |
| http://purl.uniprot.org/citations/27234056 | http://purl.uniprot.org/core/author | "Rincon M."xsd:string |
| http://purl.uniprot.org/citations/27234056 | http://purl.uniprot.org/core/author | "Fortner K.A."xsd:string |
| http://purl.uniprot.org/citations/27234056 | http://purl.uniprot.org/core/author | "Ahn K.H."xsd:string |
| http://purl.uniprot.org/citations/27234056 | http://purl.uniprot.org/core/author | "Tomas-Cortazar J."xsd:string |
| http://purl.uniprot.org/citations/27234056 | http://purl.uniprot.org/core/author | "Champagne D.P."xsd:string |
| http://purl.uniprot.org/citations/27234056 | http://purl.uniprot.org/core/author | "Torralba D."xsd:string |
| http://purl.uniprot.org/citations/27234056 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27234056 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/27234056 | http://purl.uniprot.org/core/pages | "1299-1311"xsd:string |
| http://purl.uniprot.org/citations/27234056 | http://purl.uniprot.org/core/title | "Fine-Tuning of CD8(+) T Cell Mitochondrial Metabolism by the Respiratory Chain Repressor MCJ Dictates Protection to Influenza Virus."xsd:string |
| http://purl.uniprot.org/citations/27234056 | http://purl.uniprot.org/core/volume | "44"xsd:string |
| http://purl.uniprot.org/citations/27234056 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27234056 |
| http://purl.uniprot.org/citations/27234056 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27234056 |
| http://purl.uniprot.org/uniprot/#_A0A2K6EDK0-mappedCitation-27234056 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27234056 |