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http://purl.uniprot.org/citations/27236152http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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 Background and aim. Leukocyte antigen DQ (HLA-DQ) and interferon-λ4 (IFNL4) gene polymorphisms were associated with susceptibility to chronic hepatitis B and C virus infection. This study further confirmed that variants of these genes were associated with susceptibility and spontaneous clearance of HBV infection in a Chinese population.

Material and methods

A total of 1,069 subjects were recruited and divided into three groups i.e. 397 with CLD (HBV-related chronic liver disease), 434 with SC (spontaneous clearance), and 238 HC (healthy controls). HLA-DQrs9275319 and IFNL4rs368234815, rs12971396, rs12979860, and rs8099917SNPs were genotyped using the Sequenom MassARRAY MALDI-TOF system.

Results

HLA-DQ rs9275319 showed a significant association with HBV infection (allele model, OR, 0.514; 95% CI, 0.359-0.738, adjusted p = 0.0003) and with natural clearance (allele model, OR, 1.659; 95% CI, 1.197-2.300, adjusted. However, there was no association between IFNL4 polymorphism and HBV susceptibility or natural clearance (all p > 0.05). The multifactor dimensionality reduction (MDR) test with permutation correction showed that a three-way interaction between IFNL4 and HLA-DQ SNPs was identified for HBV susceptibility (permutation p = 0.009 for the best factor model) and clearance (permutation p = 0.014 for the best factor model).

Conclusions

The data from the current study provided additional evidence for an SNP-SNP interaction between HLA-DQ and IFNL4 in regulation to HBV infection and natural clearance."xsd:string
http://purl.uniprot.org/citations/27236152http://purl.uniprot.org/core/author"Hu J."xsd:string
http://purl.uniprot.org/citations/27236152http://purl.uniprot.org/core/author"Peng H."xsd:string
http://purl.uniprot.org/citations/27236152http://purl.uniprot.org/core/author"Guo J.J."xsd:string
http://purl.uniprot.org/citations/27236152http://purl.uniprot.org/core/author"Fan J.H."xsd:string
http://purl.uniprot.org/citations/27236152http://purl.uniprot.org/core/author"Hou S.H."xsd:string
http://purl.uniprot.org/citations/27236152http://purl.uniprot.org/core/author"Qing-Ling L."xsd:string
http://purl.uniprot.org/citations/27236152http://purl.uniprot.org/core/date"2016"xsd:gYear
http://purl.uniprot.org/citations/27236152http://purl.uniprot.org/core/name"Ann Hepatol"xsd:string
http://purl.uniprot.org/citations/27236152http://purl.uniprot.org/core/pages"532-539"xsd:string
http://purl.uniprot.org/citations/27236152http://purl.uniprot.org/core/title"Association of HLA-DQ and IFNL4 polymorphisms with susceptibility to hepatitis B virus infection and clearance."xsd:string
http://purl.uniprot.org/citations/27236152http://purl.uniprot.org/core/volume"15"xsd:string
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