| http://purl.uniprot.org/citations/27238081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27238081 | http://www.w3.org/2000/01/rdf-schema#comment | "Androgen receptor (AR) signaling is a key driver of prostate cancer (PC). While androgen-deprivation therapy is transiently effective in advanced disease, tumors often progress to a lethal castration-resistant state (CRPC). We show that recurrent PC-driver mutations in speckle-type POZ protein (SPOP) stabilize the TRIM24 protein, which promotes proliferation under low androgen conditions. TRIM24 augments AR signaling, and AR and TRIM24 co-activated genes are significantly upregulated in CRPC. Expression of TRIM24 protein increases from primary PC to CRPC, and both TRIM24 protein levels and the AR/TRIM24 gene signature predict disease recurrence. Analyses in CRPC cells reveal that the TRIM24 bromodomain and the AR-interacting motif are essential to support proliferation. These data provide a rationale for therapeutic TRIM24 targeting in SPOP mutant and CRPC patients."xsd:string |
| http://purl.uniprot.org/citations/27238081 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccell.2016.04.012"xsd:string |
| http://purl.uniprot.org/citations/27238081 | http://purl.uniprot.org/core/author | "Brown M."xsd:string |
| http://purl.uniprot.org/citations/27238081 | http://purl.uniprot.org/core/author | "Aebersold R."xsd:string |
| http://purl.uniprot.org/citations/27238081 | http://purl.uniprot.org/core/author | "Fritz C."xsd:string |
| http://purl.uniprot.org/citations/27238081 | http://purl.uniprot.org/core/author | "Gu L."xsd:string |
| http://purl.uniprot.org/citations/27238081 | http://purl.uniprot.org/core/author | "Garraway L.A."xsd:string |
| http://purl.uniprot.org/citations/27238081 | http://purl.uniprot.org/core/author | "Guo T."xsd:string |
| http://purl.uniprot.org/citations/27238081 | http://purl.uniprot.org/core/author | "Zhong Q."xsd:string |
| http://purl.uniprot.org/citations/27238081 | http://purl.uniprot.org/core/author | "Fankhauser C."xsd:string |
| http://purl.uniprot.org/citations/27238081 | http://purl.uniprot.org/core/author | "Wagner U."xsd:string |
| http://purl.uniprot.org/citations/27238081 | http://purl.uniprot.org/core/author | "Cato A.C.B."xsd:string |
| http://purl.uniprot.org/citations/27238081 | http://purl.uniprot.org/core/author | "Houtman R."xsd:string |
| http://purl.uniprot.org/citations/27238081 | http://purl.uniprot.org/core/author | "Melchers D."xsd:string |
| http://purl.uniprot.org/citations/27238081 | http://purl.uniprot.org/core/author | "Theurillat J.P."xsd:string |
| http://purl.uniprot.org/citations/27238081 | http://purl.uniprot.org/core/author | "Bernasocchi T."xsd:string |
| http://purl.uniprot.org/citations/27238081 | http://purl.uniprot.org/core/author | "Tschopp P."xsd:string |
| http://purl.uniprot.org/citations/27238081 | http://purl.uniprot.org/core/author | "Wild P.J."xsd:string |
| http://purl.uniprot.org/citations/27238081 | http://purl.uniprot.org/core/author | "Groner A.C."xsd:string |
| http://purl.uniprot.org/citations/27238081 | http://purl.uniprot.org/core/author | "Janouskova H."xsd:string |
| http://purl.uniprot.org/citations/27238081 | http://purl.uniprot.org/core/author | "Corsinotti A."xsd:string |
| http://purl.uniprot.org/citations/27238081 | http://purl.uniprot.org/core/author | "Cato L."xsd:string |
| http://purl.uniprot.org/citations/27238081 | http://purl.uniprot.org/core/author | "Poyet C."xsd:string |
| http://purl.uniprot.org/citations/27238081 | http://purl.uniprot.org/core/author | "de Tribolet-Hardy J."xsd:string |