| http://purl.uniprot.org/citations/27248291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27248291 | http://www.w3.org/2000/01/rdf-schema#comment | "Rho family GTPases such as Cdc42 are key regulators of essential cellular processes through their effects on cytoskeletal dynamics, signaling and gene expression. Rho GTPases modulate these functions by engaging a wide variety of downstream effectors. Among these effectors is the largely understudied Cdc42EP/BORG family of Cdc42 effectors. BORG proteins have been linked to actin and septin regulation, but their role in development and disease is only starting to emerge. Recently, Cdc42EP3/BORG2 was shown to coordinate actin and septin cytoskeleton rearrangements in cancer-associated fibroblasts (CAFs). Interestingly, Cdc42EP3 expression potentiated cellular responses to mechanical stimulation leading to signaling and transcriptional adaptations required for the emergence of a fully activated CAF phenotype. These findings uncover a novel role for the BORG/septin network in cancer. Here, we demonstrate that Cdc42EP3 function in CAFs relies on tight regulation by Cdc42."xsd:string |
| http://purl.uniprot.org/citations/27248291 | http://purl.org/dc/terms/identifier | "doi:10.1080/21541248.2016.1194952"xsd:string |
| http://purl.uniprot.org/citations/27248291 | http://purl.uniprot.org/core/author | "Calvo F."xsd:string |
| http://purl.uniprot.org/citations/27248291 | http://purl.uniprot.org/core/author | "Farrugia A.J."xsd:string |
| http://purl.uniprot.org/citations/27248291 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/27248291 | http://purl.uniprot.org/core/name | "Small GTPases"xsd:string |
| http://purl.uniprot.org/citations/27248291 | http://purl.uniprot.org/core/pages | "49-57"xsd:string |
| http://purl.uniprot.org/citations/27248291 | http://purl.uniprot.org/core/title | "Cdc42 regulates Cdc42EP3 function in cancer-associated fibroblasts."xsd:string |
| http://purl.uniprot.org/citations/27248291 | http://purl.uniprot.org/core/volume | "8"xsd:string |
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