| http://purl.uniprot.org/citations/27260305 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27260305 | http://www.w3.org/2000/01/rdf-schema#comment | "When faced with suboptimal growth conditions, Caenorhabditis elegans larvae can enter a diapause-like stage called "dauer" that is specialized for dispersal and survival. The decision to form a dauer larva is controlled by three parallel signaling pathways, whereby a compromise of TGFβ, cyclic guanosine monophosphate, or insulin/IGF-like signaling (ILS) results in dauer formation. Signals from these pathways converge on DAF-12, a nuclear hormone receptor that triggers the changes required to initiate dauer formation. DAF-12 is related to the vitamin D, liver-X, and androstane receptors, and like these human receptors, it responds to lipophilic hormone ligands. When bound to its ligand, DAF-12 acquires transcriptional activity that directs reproductive development, while unliganded DAF-12 forms a dauer-specifying complex with its interacting protein DIN-1S to regulate the transcription of genes required for dauer development. We report here that din-1S is required in parallel to par-4/LKB1 signaling within the gonad to establish cell cycle quiescence during the onset of the dauer stage. We show that din-1S is important for postdauer reproduction when ILS is impaired and is necessary for long-term dauer survival in response to reduced ILS. Our work uncovers several previously uncharacterized functions of DIN-1S in executing and maintaining many of the cellular and physiological processes required for appropriate dauer arrest, while also shedding light on the coordination of nuclear hormone signaling, the LKB1/AMPK signaling cascade, and ILS/TGFβ in the control of cell cycle quiescence and tissue growth: a key feature that is often misregulated in a number of hormone-dependent cancers."xsd:string |
| http://purl.uniprot.org/citations/27260305 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.116.191858"xsd:string |
| http://purl.uniprot.org/citations/27260305 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/27260305 | http://purl.uniprot.org/core/author | "Roy R."xsd:string |
| http://purl.uniprot.org/citations/27260305 | http://purl.uniprot.org/core/author | "Colella E."xsd:string |
| http://purl.uniprot.org/citations/27260305 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27260305 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/27260305 | http://purl.uniprot.org/core/pages | "1763-1776"xsd:string |
| http://purl.uniprot.org/citations/27260305 | http://purl.uniprot.org/core/title | "Developmental and Cell Cycle Quiescence Is Mediated by the Nuclear Hormone Receptor Coregulator DIN-1S in the Caenorhabditis elegans Dauer Larva."xsd:string |
| http://purl.uniprot.org/citations/27260305 | http://purl.uniprot.org/core/volume | "203"xsd:string |
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