| http://purl.uniprot.org/citations/27272733 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27272733 | http://www.w3.org/2000/01/rdf-schema#comment | "EHBP-1 (Ehbp1) is a conserved regulator of endocytic recycling, acting as an effector of small GTPases including RAB-10 (Rab10). Here we present evidence that EHBP-1 associates with tubular endosomal phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] enriched membranes through an N-terminal C2-like (NT-C2) domain, and define residues within the NT-C2 domain that mediate membrane interaction. Furthermore, our results indicate that the EHBP-1 central calponin homology (CH) domain binds to actin microfilaments in a reaction that is stimulated by RAB-10(GTP). Loss of any aspect of this RAB-10/EHBP-1 system in the C. elegans intestinal epithelium leads to retention of basolateral recycling cargo in endosomes that have lost their normal tubular endosomal network (TEN) organization. We propose a mechanism whereby RAB-10 promotes the ability of endosome-bound EHBP-1 to also bind to the actin cytoskeleton, thereby promoting endosomal tubulation."xsd:string |
| http://purl.uniprot.org/citations/27272733 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1006093"xsd:string |
| http://purl.uniprot.org/citations/27272733 | http://purl.uniprot.org/core/author | "Liu H."xsd:string |
| http://purl.uniprot.org/citations/27272733 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/27272733 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/27272733 | http://purl.uniprot.org/core/author | "Shi A."xsd:string |
| http://purl.uniprot.org/citations/27272733 | http://purl.uniprot.org/core/author | "Yang Z."xsd:string |
| http://purl.uniprot.org/citations/27272733 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/27272733 | http://purl.uniprot.org/core/author | "Wang P."xsd:string |
| http://purl.uniprot.org/citations/27272733 | http://purl.uniprot.org/core/author | "Grant B.D."xsd:string |
| http://purl.uniprot.org/citations/27272733 | http://purl.uniprot.org/core/author | "Liu O."xsd:string |
| http://purl.uniprot.org/citations/27272733 | http://purl.uniprot.org/core/author | "Gleason A."xsd:string |
| http://purl.uniprot.org/citations/27272733 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27272733 | http://purl.uniprot.org/core/name | "PLoS Genet"xsd:string |
| http://purl.uniprot.org/citations/27272733 | http://purl.uniprot.org/core/pages | "e1006093"xsd:string |
| http://purl.uniprot.org/citations/27272733 | http://purl.uniprot.org/core/title | "RAB-10 Promotes EHBP-1 Bridging of Filamentous Actin and Tubular Recycling Endosomes."xsd:string |
| http://purl.uniprot.org/citations/27272733 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/27272733 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27272733 |
| http://purl.uniprot.org/citations/27272733 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27272733 |
| http://purl.uniprot.org/uniprot/#_G5ECW3-mappedCitation-27272733 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27272733 |
| http://purl.uniprot.org/uniprot/#_Q94148-mappedCitation-27272733 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27272733 |
| http://purl.uniprot.org/uniprot/Q94148 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27272733 |
| http://purl.uniprot.org/uniprot/G5ECW3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27272733 |