| http://purl.uniprot.org/citations/27273476 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27273476 | http://www.w3.org/2000/01/rdf-schema#comment | "A periplasmic flagellar chaperone protein, FlgA, is required for P-ring assembly in bacterial flagella of taxa such as Salmonella enterica or Escherichia coli. The mechanism of chaperone-mediated P-ring formation is poorly understood. Here we present the open and closed crystal structures of FlgA from Salmonella enterica serovar Typhimurium, grown under different crystallization conditions. An intramolecular disulfide cross-linked form of FlgA caused a dominant negative effect on motility of the wild-type strain. Pull-down experiments support a specific protein-protein interaction between FlgI, the P-ring component protein, and the C-terminal domain of FlgA. Surface plasmon resonance and limited-proteolysis indicate that flexibility of the domain is reduced in the covalently closed form. These results show that the structural flexibility of the C-terminal domain of FlgA, which is related to the structural difference between the two crystal forms, is intrinsically associated with its molecular chaperone function in P-ring assembly."xsd:string |
| http://purl.uniprot.org/citations/27273476 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep27399"xsd:string |
| http://purl.uniprot.org/citations/27273476 | http://purl.uniprot.org/core/author | "Namba K."xsd:string |
| http://purl.uniprot.org/citations/27273476 | http://purl.uniprot.org/core/author | "Matsunami H."xsd:string |
| http://purl.uniprot.org/citations/27273476 | http://purl.uniprot.org/core/author | "Samatey F.A."xsd:string |
| http://purl.uniprot.org/citations/27273476 | http://purl.uniprot.org/core/author | "Meshcheryakov V.A."xsd:string |
| http://purl.uniprot.org/citations/27273476 | http://purl.uniprot.org/core/author | "Yoon Y.H."xsd:string |
| http://purl.uniprot.org/citations/27273476 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27273476 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/27273476 | http://purl.uniprot.org/core/pages | "27399"xsd:string |
| http://purl.uniprot.org/citations/27273476 | http://purl.uniprot.org/core/title | "Structural flexibility of the periplasmic protein, FlgA, regulates flagellar P-ring assembly in Salmonella enterica."xsd:string |
| http://purl.uniprot.org/citations/27273476 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/27273476 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27273476 |
| http://purl.uniprot.org/citations/27273476 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27273476 |
| http://purl.uniprot.org/uniprot/#_P40131-mappedCitation-27273476 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27273476 |
| http://purl.uniprot.org/uniprot/P40131 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27273476 |