| http://purl.uniprot.org/citations/27273576 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27273576 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27273576 | http://www.w3.org/2000/01/rdf-schema#comment | "A coding polymorphism of human ATG16L1 (rs2241880; T300A) increases the risk of Crohn's disease and it has been shown to enhance susceptibility of ATG16L1 to caspase cleavage. Here we show that T300A also alters the ability of the C-terminal WD40-repeat domain of ATG16L1 to interact with an amino acid motif that recognizes this region. Such alteration impairs the unconventional autophagic activity of TMEM59, a transmembrane protein that contains the WD40 domain-binding motif, and disrupts its normal intracellular trafficking and its ability to engage ATG16L1 in response to bacterial infection. TMEM59-induced autophagy is blunted in cells expressing the fragments generated by caspase processing of the ATG16L1-T300A risk allele, whereas canonical autophagy remains unaffected. These results suggest that the T300A polymorphism alters the function of motif-containing molecules that engage ATG16L1 through the WD40 domain, either by influencing this interaction under non-stressful conditions or by inhibiting their downstream autophagic signalling after caspase-mediated cleavage."xsd:string |
| http://purl.uniprot.org/citations/27273576 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms11821"xsd:string |
| http://purl.uniprot.org/citations/27273576 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms11821"xsd:string |
| http://purl.uniprot.org/citations/27273576 | http://purl.uniprot.org/core/author | "Xavier R.J."xsd:string |
| http://purl.uniprot.org/citations/27273576 | http://purl.uniprot.org/core/author | "Xavier R.J."xsd:string |
| http://purl.uniprot.org/citations/27273576 | http://purl.uniprot.org/core/author | "Boada-Romero E."xsd:string |
| http://purl.uniprot.org/citations/27273576 | http://purl.uniprot.org/core/author | "Boada-Romero E."xsd:string |
| http://purl.uniprot.org/citations/27273576 | http://purl.uniprot.org/core/author | "Boone D.L."xsd:string |
| http://purl.uniprot.org/citations/27273576 | http://purl.uniprot.org/core/author | "Boone D.L."xsd:string |
| http://purl.uniprot.org/citations/27273576 | http://purl.uniprot.org/core/author | "Pimentel-Muinos F.X."xsd:string |
| http://purl.uniprot.org/citations/27273576 | http://purl.uniprot.org/core/author | "Pimentel-Muinos F.X."xsd:string |
| http://purl.uniprot.org/citations/27273576 | http://purl.uniprot.org/core/author | "Sacristan M.P."xsd:string |
| http://purl.uniprot.org/citations/27273576 | http://purl.uniprot.org/core/author | "Sacristan M.P."xsd:string |
| http://purl.uniprot.org/citations/27273576 | http://purl.uniprot.org/core/author | "Serramito-Gomez I."xsd:string |
| http://purl.uniprot.org/citations/27273576 | http://purl.uniprot.org/core/author | "Serramito-Gomez I."xsd:string |
| http://purl.uniprot.org/citations/27273576 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27273576 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27273576 | http://purl.uniprot.org/core/name | "Nat. Commun."xsd:string |
| http://purl.uniprot.org/citations/27273576 | http://purl.uniprot.org/core/name | "Nat. Commun."xsd:string |
| http://purl.uniprot.org/citations/27273576 | http://purl.uniprot.org/core/pages | "11821"xsd:string |
| http://purl.uniprot.org/citations/27273576 | http://purl.uniprot.org/core/pages | "11821"xsd:string |
| http://purl.uniprot.org/citations/27273576 | http://purl.uniprot.org/core/title | "The T300A Crohn's disease risk polymorphism impairs function of the WD40 domain of ATG16L1."xsd:string |
| http://purl.uniprot.org/citations/27273576 | http://purl.uniprot.org/core/title | "The T300A Crohn's disease risk polymorphism impairs function of the WD40 domain of ATG16L1."xsd:string |