| http://purl.uniprot.org/citations/27280403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27280403 | http://www.w3.org/2000/01/rdf-schema#comment | "Human CD4 T cells are constantly exposed to IL-12 during infections and certain autoimmune disorders. The current paradigm is that IL-12 promotes the differentiation of naïve CD4 T cells into Th1 cells, but recent studies suggest IL-12 may play a more complex role in T cell biology. We examined if exposure to IL-12 alters human CD4 T cell responses to subsequent TCR stimulation. We found that IL-12 pretreatment increased TCR-induced IFN-γ, TNF-α, IL-13, IL-4 and IL-10 production. This suggests that prior exposure to IL-12 potentiates the TCR-induced release of a range of cytokines. We observed that IL-12 mediated its effects through both transcriptional and post-transcriptional mechanisms. IL-12 pretreatment increased the phosphorylation of AKT, p38 and LCK following TCR stimulation without altering other TCR signaling molecules, potentially mediating the increase in transcription of cytokines. In addition, the IL-12-mediated enhancement of cytokines that are not transcriptionally regulated was partially driven by increased oxidative metabolism. Our data uncover a novel function of IL-12 in human CD4 T cells; specifically, it enhances the release of a range of cytokines potentially by altering TCR signaling pathways and by enhancing oxidative metabolism."xsd:string |
| http://purl.uniprot.org/citations/27280403 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0157175"xsd:string |
| http://purl.uniprot.org/citations/27280403 | http://purl.uniprot.org/core/author | "Harty J.T."xsd:string |
| http://purl.uniprot.org/citations/27280403 | http://purl.uniprot.org/core/author | "Houtman J.C."xsd:string |
| http://purl.uniprot.org/citations/27280403 | http://purl.uniprot.org/core/author | "Chapman N.M."xsd:string |
| http://purl.uniprot.org/citations/27280403 | http://purl.uniprot.org/core/author | "Richer M.J."xsd:string |
| http://purl.uniprot.org/citations/27280403 | http://purl.uniprot.org/core/author | "Vacaflores A."xsd:string |
| http://purl.uniprot.org/citations/27280403 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27280403 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/27280403 | http://purl.uniprot.org/core/pages | "e0157175"xsd:string |
| http://purl.uniprot.org/citations/27280403 | http://purl.uniprot.org/core/title | "Exposure of Human CD4 T Cells to IL-12 Results in Enhanced TCR-Induced Cytokine Production, Altered TCR Signaling, and Increased Oxidative Metabolism."xsd:string |
| http://purl.uniprot.org/citations/27280403 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/27280403 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27280403 |
| http://purl.uniprot.org/citations/27280403 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27280403 |
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| http://purl.uniprot.org/uniprot/#_B5BUQ6-mappedCitation-27280403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27280403 |
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