| http://purl.uniprot.org/citations/27282340 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27282340 | http://www.w3.org/2000/01/rdf-schema#comment | "Extracellular vesicles (EVs) are membrane-enclosed nanoparticles containing specific repertoires of genetic material. In mammals, EVs can mediate the horizontal transfer of various cargos and signaling molecules, notably miRNA and mRNA species. Whether this form of intercellular communication prevails in other metazoans remains unclear. Here, we report the first parallel comparative morphologic and transcriptomic characterization of EVs from Drosophila and human cellular models. Electronic microscopy revealed that human and Drosophila cells release similar EVs with diameters ranging from 30 to 200 nm, which contain complex populations of transcripts. RNA-seq identified abundant ribosomal RNAs, related pseudogenes and retrotransposons in human and Drosophila EVs. Vault RNAs and Y RNAs abounded in human samples, whereas small nucleolar RNAs involved in pseudouridylation were most prevalent in Drosophila EVs. Numerous mRNAs were identified, largely consisting of exonic sequences displaying full-length read coverage and enriched for translation and electronic transport chain functions. By analogy with human systems, these sizeable similarities suggest that EVs could potentially enable RNA-mediated intercellular communication in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/27282340 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep27680"xsd:string |
| http://purl.uniprot.org/citations/27282340 | http://purl.uniprot.org/core/author | "Garnier D."xsd:string |
| http://purl.uniprot.org/citations/27282340 | http://purl.uniprot.org/core/author | "Blanchet-Cohen A."xsd:string |
| http://purl.uniprot.org/citations/27282340 | http://purl.uniprot.org/core/author | "Lecuyer E."xsd:string |
| http://purl.uniprot.org/citations/27282340 | http://purl.uniprot.org/core/author | "Lefebvre F.A."xsd:string |
| http://purl.uniprot.org/citations/27282340 | http://purl.uniprot.org/core/author | "Rak J."xsd:string |
| http://purl.uniprot.org/citations/27282340 | http://purl.uniprot.org/core/author | "Benoit Bouvrette L.P."xsd:string |
| http://purl.uniprot.org/citations/27282340 | http://purl.uniprot.org/core/author | "Perras L."xsd:string |
| http://purl.uniprot.org/citations/27282340 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27282340 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/27282340 | http://purl.uniprot.org/core/pages | "27680"xsd:string |
| http://purl.uniprot.org/citations/27282340 | http://purl.uniprot.org/core/title | "Comparative transcriptomic analysis of human and Drosophila extracellular vesicles."xsd:string |
| http://purl.uniprot.org/citations/27282340 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/27282340 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27282340 |
| http://purl.uniprot.org/citations/27282340 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27282340 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DHM8-mappedCitation-27282340 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27282340 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DHN5-mappedCitation-27282340 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27282340 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LF57-mappedCitation-27282340 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27282340 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K6U6-mappedCitation-27282340 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27282340 |
| http://purl.uniprot.org/uniprot/#_A0A1W5Q0S1-mappedCitation-27282340 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27282340 |
| http://purl.uniprot.org/uniprot/#_A0A0B4JCV9-mappedCitation-27282340 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27282340 |
| http://purl.uniprot.org/uniprot/#_A8DYG7-mappedCitation-27282340 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27282340 |
| http://purl.uniprot.org/uniprot/#_E1JHR9-mappedCitation-27282340 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27282340 |