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http://purl.uniprot.org/citations/27283469http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/27283469http://www.w3.org/2000/01/rdf-schema#comment"In the developing Drosophila brain, a small number of neural progenitor cells (neuroblasts) generate in a co-ordinated manner a high variety of neuronal cells by integration of temporal, spatial and cell-intrinsic information. In this study, we performed the molecular and phenotypic characterization of a structural brain mutant called small mushroom bodies (smu), which was isolated in a screen for mutants with altered brain structure. Focusing on the mushroom body neuroblast lineages we show that failure of neuroblasts to generate the normal number of mushroom body neurons (Kenyon cells) is the major cause of the smu phenotype. In particular, the premature loss of mushroom body neuroblasts caused a pronounced effect on the number of late-born Kenyon cells. Neuroblasts showed no obvious defects in processes controlling asymmetric cell division, but generated less ganglion mother cells. Cloning of smu uncovered a single amino acid substitution in an evolutionarily conserved protein interaction domain of the Minichromosome maintenance 3 (Mcm3) protein. Mcm3 is part of the multimeric Cdc45/Mcm/GINS (CMG) complex, which functions as a helicase during DNA replication. We propose that at least in the case of mushroom body neuroblasts, timely replication is not only required for continuous proliferation but also for their survival. The absence of Kenyon cells in smu reduced learning and early phases of conditioned olfactory memory. Corresponding to the absence of late-born Kenyon cells projecting to α'/β' and α/β lobes, smu is profoundly defective in later phases of persistent memory."xsd:string
http://purl.uniprot.org/citations/27283469http://purl.org/dc/terms/identifier"doi:10.1111/gbb.12304"xsd:string
http://purl.uniprot.org/citations/27283469http://purl.uniprot.org/core/author"Berger C."xsd:string
http://purl.uniprot.org/citations/27283469http://purl.uniprot.org/core/author"Raabe T."xsd:string
http://purl.uniprot.org/citations/27283469http://purl.uniprot.org/core/author"Serway C.N."xsd:string
http://purl.uniprot.org/citations/27283469http://purl.uniprot.org/core/author"de Belle J.S."xsd:string
http://purl.uniprot.org/citations/27283469http://purl.uniprot.org/core/author"Mentzel B."xsd:string
http://purl.uniprot.org/citations/27283469http://purl.uniprot.org/core/author"Blumroder R."xsd:string
http://purl.uniprot.org/citations/27283469http://purl.uniprot.org/core/author"Dunkelberger B.S."xsd:string
http://purl.uniprot.org/citations/27283469http://purl.uniprot.org/core/author"Glunz A."xsd:string
http://purl.uniprot.org/citations/27283469http://purl.uniprot.org/core/date"2016"xsd:gYear
http://purl.uniprot.org/citations/27283469http://purl.uniprot.org/core/name"Genes Brain Behav"xsd:string
http://purl.uniprot.org/citations/27283469http://purl.uniprot.org/core/pages"647-659"xsd:string
http://purl.uniprot.org/citations/27283469http://purl.uniprot.org/core/title"Mcm3 replicative helicase mutation impairs neuroblast proliferation and memory in Drosophila."xsd:string
http://purl.uniprot.org/citations/27283469http://purl.uniprot.org/core/volume"15"xsd:string
http://purl.uniprot.org/citations/27283469http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/27283469
http://purl.uniprot.org/citations/27283469http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/27283469
http://purl.uniprot.org/uniprot/Q7JNE2#attribution-27275E039CA2A6BBEBFDF9C2ABE7B31Ahttp://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/27283469
http://purl.uniprot.org/uniprot/X2JAI4#attribution-27275E039CA2A6BBEBFDF9C2ABE7B31Ahttp://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/27283469
http://purl.uniprot.org/uniprot/#_A0A0B4LEV2-mappedCitation-27283469http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27283469
http://purl.uniprot.org/uniprot/#_A8JUY0-mappedCitation-27283469http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27283469
http://purl.uniprot.org/uniprot/#_Q26454-mappedCitation-27283469http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27283469
http://purl.uniprot.org/uniprot/#_Q7JNE2-mappedCitation-27283469http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27283469
http://purl.uniprot.org/uniprot/#_Q7JNE3-mappedCitation-27283469http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27283469