| http://purl.uniprot.org/citations/27284108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27284108 | http://www.w3.org/2000/01/rdf-schema#comment | "Pancreatic islet β-cells are particularly susceptible to endoplasmic reticulum (ER) stress, which is implicated in β-cell dysfunction and loss during the pathogenesis of type 1 diabetes (T1D). The peripheral membrane protein GAD65 is an autoantigen in human T1D. GAD65 synthesizes γ-aminobutyric acid, an important autocrine and paracrine signaling molecule and a survival factor in islets. We show that ER stress in primary β-cells perturbs the palmitoylation cycle controlling GAD65 endomembrane distribution, resulting in aberrant accumulation of the palmitoylated form in trans-Golgi membranes. The palmitoylated form has heightened immunogenicity, exhibiting increased uptake by antigen-presenting cells and T-cell stimulation compared with the nonpalmitoylated form. Similar accumulation of GAD65 in Golgi membranes is observed in human β-cells in pancreatic sections from GAD65 autoantibody-positive individuals who have not yet progressed to clinical onset of T1D and from patients with T1D with residual β-cell mass and ongoing T-cell infiltration of islets. We propose that aberrant accumulation of immunogenic GAD65 in Golgi membranes facilitates inappropriate presentation to the immune system after release from stressed and/or damaged β-cells, triggering autoimmunity."xsd:string |
| http://purl.uniprot.org/citations/27284108 | http://purl.org/dc/terms/identifier | "doi:10.2337/db16-0180"xsd:string |
| http://purl.uniprot.org/citations/27284108 | http://purl.uniprot.org/core/author | "Kanaani J."xsd:string |
| http://purl.uniprot.org/citations/27284108 | http://purl.uniprot.org/core/author | "Lavallard V."xsd:string |
| http://purl.uniprot.org/citations/27284108 | http://purl.uniprot.org/core/author | "Baekkeskov S."xsd:string |
| http://purl.uniprot.org/citations/27284108 | http://purl.uniprot.org/core/author | "Billestrup N."xsd:string |
| http://purl.uniprot.org/citations/27284108 | http://purl.uniprot.org/core/author | "Michael I.P."xsd:string |
| http://purl.uniprot.org/citations/27284108 | http://purl.uniprot.org/core/author | "Hubbell J.A."xsd:string |
| http://purl.uniprot.org/citations/27284108 | http://purl.uniprot.org/core/author | "Nano R."xsd:string |
| http://purl.uniprot.org/citations/27284108 | http://purl.uniprot.org/core/author | "Pasquier M."xsd:string |
| http://purl.uniprot.org/citations/27284108 | http://purl.uniprot.org/core/author | "Phelps E.A."xsd:string |
| http://purl.uniprot.org/citations/27284108 | http://purl.uniprot.org/core/author | "Cianciaruso C."xsd:string |
| http://purl.uniprot.org/citations/27284108 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27284108 | http://purl.uniprot.org/core/name | "Diabetes"xsd:string |
| http://purl.uniprot.org/citations/27284108 | http://purl.uniprot.org/core/pages | "2686-2699"xsd:string |
| http://purl.uniprot.org/citations/27284108 | http://purl.uniprot.org/core/title | "Aberrant Accumulation of the Diabetes Autoantigen GAD65 in Golgi Membranes in Conditions of ER Stress and Autoimmunity."xsd:string |
| http://purl.uniprot.org/citations/27284108 | http://purl.uniprot.org/core/volume | "65"xsd:string |
| http://purl.uniprot.org/citations/27284108 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27284108 |
| http://purl.uniprot.org/citations/27284108 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27284108 |
| http://purl.uniprot.org/uniprot/#_Q5VZ30-mappedCitation-27284108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27284108 |
| http://purl.uniprot.org/uniprot/#_Q05329-mappedCitation-27284108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27284108 |
| http://purl.uniprot.org/uniprot/#_Q4G154-mappedCitation-27284108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27284108 |
| http://purl.uniprot.org/uniprot/#_Q6ZSK1-mappedCitation-27284108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27284108 |
| http://purl.uniprot.org/uniprot/#_Q9UGI5-mappedCitation-27284108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27284108 |