| http://purl.uniprot.org/citations/27292635 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27292635 | http://www.w3.org/2000/01/rdf-schema#comment | "Cancer immunotherapies are more effective in tumors with robust T cell infiltrates, but mechanisms to convert T cell-devoid tumors with active immunosuppression to those capable of recruiting T cells remain incompletely understood. Here, using genetically engineered mouse models of pancreatic ductal adenocarcinoma (PDA), we demonstrate that a single dose of agonistic CD40 antibody with chemotherapy rendered PDA susceptible to T cell-dependent destruction and potentiated durable remissions. CD40 stimulation caused a clonal expansion of T cells in the tumor, but the addition of chemotherapy optimized myeloid activation and T cell function. Although recent data highlight the requirement for innate sensors in cancer immunity, these canonical pathways-including TLRs, inflammasome, and type I interferon/STING-played no role in mediating the efficacy of CD40 and chemotherapy. Thus, CD40 functions as a non-redundant mechanism to convert the tumor microenvironment immunologically. Our data provide a rationale for a newly initiated clinical trial of CD40 and chemotherapy in PDA."xsd:string |
| http://purl.uniprot.org/citations/27292635 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2016.05.058"xsd:string |
| http://purl.uniprot.org/citations/27292635 | http://purl.uniprot.org/core/author | "Vonderheide R.H."xsd:string |
| http://purl.uniprot.org/citations/27292635 | http://purl.uniprot.org/core/author | "Byrne K.T."xsd:string |
| http://purl.uniprot.org/citations/27292635 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27292635 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/27292635 | http://purl.uniprot.org/core/pages | "2719-2732"xsd:string |
| http://purl.uniprot.org/citations/27292635 | http://purl.uniprot.org/core/title | "CD40 Stimulation Obviates Innate Sensors and Drives T Cell Immunity in Cancer."xsd:string |
| http://purl.uniprot.org/citations/27292635 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/27292635 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27292635 |
| http://purl.uniprot.org/citations/27292635 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27292635 |
| http://purl.uniprot.org/uniprot/#_A0A125R9I3-mappedCitation-27292635 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27292635 |
| http://purl.uniprot.org/uniprot/#_A0A075B5P6-mappedCitation-27292635 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27292635 |
| http://purl.uniprot.org/uniprot/#_A0A075B6A0-mappedCitation-27292635 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27292635 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SVY1-mappedCitation-27292635 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27292635 |
| http://purl.uniprot.org/uniprot/#_E0CY92-mappedCitation-27292635 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27292635 |
| http://purl.uniprot.org/uniprot/#_Q0PM15-mappedCitation-27292635 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27292635 |
| http://purl.uniprot.org/uniprot/#_Q0PM16-mappedCitation-27292635 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27292635 |
| http://purl.uniprot.org/uniprot/#_Q0VDV7-mappedCitation-27292635 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27292635 |
| http://purl.uniprot.org/uniprot/#_A0A2R3XZC4-mappedCitation-27292635 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27292635 |
| http://purl.uniprot.org/uniprot/#_A0A7R8C347-mappedCitation-27292635 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27292635 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J210-mappedCitation-27292635 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27292635 |
| http://purl.uniprot.org/uniprot/#_A0A1S5WLE4-mappedCitation-27292635 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27292635 |
| http://purl.uniprot.org/uniprot/#_A2A5L7-mappedCitation-27292635 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27292635 |