| http://purl.uniprot.org/citations/27292644 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27292644 | http://www.w3.org/2000/01/rdf-schema#comment | "TGF-β signaling regulates a variety of cellular processes, including proliferation, apoptosis, differentiation, immune responses, and fibrogenesis. Here, we describe a lysine methylation-mediated mechanism that controls the pro-fibrogenic activity of TGF-β. We find that the methyltransferase Set9 potentiates TGF-β signaling by targeting Smad7, an inhibitory downstream effector. Smad7 methylation promotes interaction with the E3 ligase Arkadia and, thus, ubiquitination-dependent degradation. Depletion or pharmacological inhibition of Set9 results in elevated Smad7 protein levels and inhibits TGF-β-dependent expression of genes encoding extracellular matrix components. The inhibitory effect of Set9 on TGF-β-mediated extracellular matrix production is further demonstrated in mouse models of pulmonary fibrosis. Lung fibrosis induced by bleomycin or Ad-TGF-β treatment was highly compromised in Set9-deficient mice. These results uncover a complex regulatory interplay among multiple Smad7 modifications and highlight the possibility that protein methyltransferases may represent promising therapeutic targets for treating lung fibrosis."xsd:string |
| http://purl.uniprot.org/citations/27292644 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2016.05.051"xsd:string |
| http://purl.uniprot.org/citations/27292644 | http://purl.uniprot.org/core/author | "Brown P.J."xsd:string |
| http://purl.uniprot.org/citations/27292644 | http://purl.uniprot.org/core/author | "Elkouris M."xsd:string |
| http://purl.uniprot.org/citations/27292644 | http://purl.uniprot.org/core/author | "Sideras P."xsd:string |
| http://purl.uniprot.org/citations/27292644 | http://purl.uniprot.org/core/author | "Talianidis I."xsd:string |
| http://purl.uniprot.org/citations/27292644 | http://purl.uniprot.org/core/author | "Panayotou G."xsd:string |
| http://purl.uniprot.org/citations/27292644 | http://purl.uniprot.org/core/author | "Kontaki H."xsd:string |
| http://purl.uniprot.org/citations/27292644 | http://purl.uniprot.org/core/author | "Samiotaki M."xsd:string |
| http://purl.uniprot.org/citations/27292644 | http://purl.uniprot.org/core/author | "Szantai E."xsd:string |
| http://purl.uniprot.org/citations/27292644 | http://purl.uniprot.org/core/author | "Stavropoulos A."xsd:string |
| http://purl.uniprot.org/citations/27292644 | http://purl.uniprot.org/core/author | "Saviolaki D."xsd:string |
| http://purl.uniprot.org/citations/27292644 | http://purl.uniprot.org/core/author | "Nikolaou K.C."xsd:string |
| http://purl.uniprot.org/citations/27292644 | http://purl.uniprot.org/core/author | "Antonoglou A."xsd:string |
| http://purl.uniprot.org/citations/27292644 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27292644 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/27292644 | http://purl.uniprot.org/core/pages | "2733-2744"xsd:string |
| http://purl.uniprot.org/citations/27292644 | http://purl.uniprot.org/core/title | "SET9-Mediated Regulation of TGF-beta Signaling Links Protein Methylation to Pulmonary Fibrosis."xsd:string |
| http://purl.uniprot.org/citations/27292644 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/27292644 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27292644 |
| http://purl.uniprot.org/citations/27292644 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27292644 |
| http://purl.uniprot.org/uniprot/#_A0A078BBI5-mappedCitation-27292644 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27292644 |
| http://purl.uniprot.org/uniprot/#_A0A078BC11-mappedCitation-27292644 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27292644 |
| http://purl.uniprot.org/uniprot/#_A0A078BCJ0-mappedCitation-27292644 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27292644 |