| http://purl.uniprot.org/citations/27292648 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27292648 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27292648 | http://www.w3.org/2000/01/rdf-schema#comment | "The transcription factor T-bet directs Th1 cell differentiation, but the molecular mechanisms that underlie this lineage-specific gene regulation are not completely understood. Here, we show that T-bet acts through enhancers to allow the recruitment of Mediator and P-TEFb in the form of the super elongation complex (SEC). Th1 genes are occupied by H3K4me3 and RNA polymerase II in Th2 cells, while T-bet-mediated recruitment of P-TEFb in Th1 cells activates transcriptional elongation. P-TEFb is recruited to both genes and enhancers, where it activates enhancer RNA transcription. P-TEFb inhibition and Mediator and SEC knockdown selectively block activation of T-bet target genes, and P-TEFb inhibition abrogates Th1-associated experimental autoimmune uveitis. T-bet activity is independent of changes in NF-κB RelA and Brd4 binding, with T-bet- and NF-κB-mediated pathways instead converging to allow P-TEFb recruitment. These data provide insight into the mechanism through which lineage-specifying factors promote differentiation of alternative T cell fates."xsd:string |
| http://purl.uniprot.org/citations/27292648 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2016.05.054"xsd:string |
| http://purl.uniprot.org/citations/27292648 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2016.05.054"xsd:string |
| http://purl.uniprot.org/citations/27292648 | http://purl.uniprot.org/core/author | "Kelly A."xsd:string |
| http://purl.uniprot.org/citations/27292648 | http://purl.uniprot.org/core/author | "Kelly A."xsd:string |
| http://purl.uniprot.org/citations/27292648 | http://purl.uniprot.org/core/author | "Calder V.L."xsd:string |
| http://purl.uniprot.org/citations/27292648 | http://purl.uniprot.org/core/author | "Calder V.L."xsd:string |
| http://purl.uniprot.org/citations/27292648 | http://purl.uniprot.org/core/author | "Evans C.M."xsd:string |
| http://purl.uniprot.org/citations/27292648 | http://purl.uniprot.org/core/author | "Evans C.M."xsd:string |
| http://purl.uniprot.org/citations/27292648 | http://purl.uniprot.org/core/author | "Adamson P."xsd:string |
| http://purl.uniprot.org/citations/27292648 | http://purl.uniprot.org/core/author | "Adamson P."xsd:string |
| http://purl.uniprot.org/citations/27292648 | http://purl.uniprot.org/core/author | "Ambrose J."xsd:string |
| http://purl.uniprot.org/citations/27292648 | http://purl.uniprot.org/core/author | "Ambrose J."xsd:string |
| http://purl.uniprot.org/citations/27292648 | http://purl.uniprot.org/core/author | "Cousins D.J."xsd:string |
| http://purl.uniprot.org/citations/27292648 | http://purl.uniprot.org/core/author | "Cousins D.J."xsd:string |
| http://purl.uniprot.org/citations/27292648 | http://purl.uniprot.org/core/author | "Eskandarpour M."xsd:string |
| http://purl.uniprot.org/citations/27292648 | http://purl.uniprot.org/core/author | "Eskandarpour M."xsd:string |
| http://purl.uniprot.org/citations/27292648 | http://purl.uniprot.org/core/author | "Hertweck A."xsd:string |
| http://purl.uniprot.org/citations/27292648 | http://purl.uniprot.org/core/author | "Hertweck A."xsd:string |
| http://purl.uniprot.org/citations/27292648 | http://purl.uniprot.org/core/author | "Jackson I."xsd:string |
| http://purl.uniprot.org/citations/27292648 | http://purl.uniprot.org/core/author | "Jackson I."xsd:string |
| http://purl.uniprot.org/citations/27292648 | http://purl.uniprot.org/core/author | "Jenner R.G."xsd:string |
| http://purl.uniprot.org/citations/27292648 | http://purl.uniprot.org/core/author | "Jenner R.G."xsd:string |