| http://purl.uniprot.org/citations/27296282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27296282 | http://www.w3.org/2000/01/rdf-schema#comment | "Amicoumacin A is an antibiotic that was recently shown to target bacterial ribosomes. It affects translocation and provides an additional contact interface between the ribosomal RNA and mRNA. The binding site of amicoumacin A is formed by universally conserved nucleotides of rRNA. In this work, we showed that amicoumacin A inhibits translation in yeast and mammalian systems by affecting translation elongation. We determined the structure of the amicoumacin A complex with yeast ribosomes at a resolution of 3.1 Å. Toxicity measurement demonstrated that human cancer cell lines are more susceptible to the inhibition by this compound as compared to non-cancerous ones. This might be used as a starting point to develop amicoumacin A derivatives with clinical value."xsd:string |
| http://purl.uniprot.org/citations/27296282 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep27720"xsd:string |
| http://purl.uniprot.org/citations/27296282 | http://purl.uniprot.org/core/author | "Osterman I.A."xsd:string |
| http://purl.uniprot.org/citations/27296282 | http://purl.uniprot.org/core/author | "Dontsova O.A."xsd:string |
| http://purl.uniprot.org/citations/27296282 | http://purl.uniprot.org/core/author | "Yusupov M.M."xsd:string |
| http://purl.uniprot.org/citations/27296282 | http://purl.uniprot.org/core/author | "Yusupova G."xsd:string |
| http://purl.uniprot.org/citations/27296282 | http://purl.uniprot.org/core/author | "Dmitriev S.E."xsd:string |
| http://purl.uniprot.org/citations/27296282 | http://purl.uniprot.org/core/author | "Sergiev P.V."xsd:string |
| http://purl.uniprot.org/citations/27296282 | http://purl.uniprot.org/core/author | "Prokhorova I.V."xsd:string |
| http://purl.uniprot.org/citations/27296282 | http://purl.uniprot.org/core/author | "Akulich K.A."xsd:string |
| http://purl.uniprot.org/citations/27296282 | http://purl.uniprot.org/core/author | "Makeeva D.S."xsd:string |
| http://purl.uniprot.org/citations/27296282 | http://purl.uniprot.org/core/author | "Skvortsov D.A."xsd:string |
| http://purl.uniprot.org/citations/27296282 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27296282 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/27296282 | http://purl.uniprot.org/core/pages | "27720"xsd:string |
| http://purl.uniprot.org/citations/27296282 | http://purl.uniprot.org/core/title | "Amicoumacin A induces cancer cell death by targeting the eukaryotic ribosome."xsd:string |
| http://purl.uniprot.org/citations/27296282 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/27296282 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27296282 |
| http://purl.uniprot.org/citations/27296282 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27296282 |
| http://purl.uniprot.org/uniprot/#_P0C0V8-mappedCitation-27296282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27296282 |
| http://purl.uniprot.org/uniprot/#_P0C0W1-mappedCitation-27296282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27296282 |
| http://purl.uniprot.org/uniprot/#_P0C2H6-mappedCitation-27296282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27296282 |
| http://purl.uniprot.org/uniprot/#_P0C2H8-mappedCitation-27296282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27296282 |
| http://purl.uniprot.org/uniprot/#_P14120-mappedCitation-27296282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27296282 |