| http://purl.uniprot.org/citations/27297022 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27297022 | http://www.w3.org/2000/01/rdf-schema#comment | "A single-nucleotide polymorphism (SNP) rs4236601 at the CAV1/CAV2 locus is associated with primary open-angle glaucoma (POAG). Rs4236601 is common in Caucasians but rare in East Asians. Here we conducted a haplotype-tagging SNP analysis followed by replication in a total of 848 POAG cases and 1574 controls drawn from 3 cities in China and 1 city in Japan. Two SNPs, rs4236601 (odds ratio [OR] = 6.25; P = 0.0086) and a tagging-SNP rs3801994 (OR = 1.32; P = 0.042), were associated with POAG in the Hong Kong Chinese cohort after age and gender adjustments. Rs4236601 was associated with POAG also in Shantou (OR = 6.09; P = 0.0037) and Beijing (OR = 3.92; P = 0.030) cohorts after age and gender adjustment, with a pooled-OR of 5.26 (P = 9.0 × 10(-6)) in Chinese; but it is non-polymorphic in the Osaka cohort. SNP rs3801994 showed a similar trend of effect in the Shantou and Beijing cohorts, with a pooled-OR of 1.23 (P = 0.022) and 1.20 (P = 0.063) in Chinese, prior to and after age and gender adjustment, respectively; but it showed a reverse effect in the Osaka cohort (OR = 0.58; P = 0.033) after the adjustments. We have thus confirmed the association of rs4236601 with POAG in different Chinese cohorts. Also, we found a common SNP rs3801994 of diverse associations with POAG between Chinese and Japanese."xsd:string |
| http://purl.uniprot.org/citations/27297022 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep27837"xsd:string |
| http://purl.uniprot.org/citations/27297022 | http://purl.uniprot.org/core/author | "Matsushita K."xsd:string |
| http://purl.uniprot.org/citations/27297022 | http://purl.uniprot.org/core/author | "Nishida K."xsd:string |
| http://purl.uniprot.org/citations/27297022 | http://purl.uniprot.org/core/author | "Zhang M."xsd:string |
| http://purl.uniprot.org/citations/27297022 | http://purl.uniprot.org/core/author | "Wang N."xsd:string |
| http://purl.uniprot.org/citations/27297022 | http://purl.uniprot.org/core/author | "Jia L."xsd:string |
| http://purl.uniprot.org/citations/27297022 | http://purl.uniprot.org/core/author | "Chen L.J."xsd:string |
| http://purl.uniprot.org/citations/27297022 | http://purl.uniprot.org/core/author | "Pang C.P."xsd:string |
| http://purl.uniprot.org/citations/27297022 | http://purl.uniprot.org/core/author | "Tsujikawa M."xsd:string |
| http://purl.uniprot.org/citations/27297022 | http://purl.uniprot.org/core/author | "Tam P.O."xsd:string |
| http://purl.uniprot.org/citations/27297022 | http://purl.uniprot.org/core/author | "Young A.L."xsd:string |
| http://purl.uniprot.org/citations/27297022 | http://purl.uniprot.org/core/author | "Hashida N."xsd:string |
| http://purl.uniprot.org/citations/27297022 | http://purl.uniprot.org/core/author | "Chiang S.W."xsd:string |
| http://purl.uniprot.org/citations/27297022 | http://purl.uniprot.org/core/author | "Miki A."xsd:string |
| http://purl.uniprot.org/citations/27297022 | http://purl.uniprot.org/core/author | "Leung C.K."xsd:string |
| http://purl.uniprot.org/citations/27297022 | http://purl.uniprot.org/core/author | "Rong S.S."xsd:string |
| http://purl.uniprot.org/citations/27297022 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27297022 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/27297022 | http://purl.uniprot.org/core/pages | "27837"xsd:string |
| http://purl.uniprot.org/citations/27297022 | http://purl.uniprot.org/core/title | "Ethnic specific association of the CAV1/CAV2 locus with primary open-angle glaucoma."xsd:string |
| http://purl.uniprot.org/citations/27297022 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/27297022 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27297022 |
| http://purl.uniprot.org/citations/27297022 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27297022 |