DESCRIBE <http://purl.uniprot.org/citations/27300270>

Subject	Predicate	Object
http://purl.uniprot.org/citations/27300270	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/27300270	http://www.w3.org/2000/01/rdf-schema#comment	" Objective Noninvasive diagnostics of early stages of coronary artery disease and discrimination between various extents of vascular lesions in patients is an important clinical problem especially considering wide spread use of cholesterol lowering drugs that affect lipid and lipoprotein profiling. The main goal of our study was to evaluate applicability of new combinations of noninvasive biomarkers such as leptin to insulin and adiponectin to endothelin ratios, for detection of early stages of coronary atherosclerosis versus later stages of the disease. Patients and methods A number of previously validated serum biomarkers were tested in a group of 500 patients with coronary artery disease and examined for their association with severity of coronary lesion according to Gensini score determined by coronary angiography. Results Lowest extent of coronary lesions was associated with significant increase in apoA-I levels and with significantly increased ratios of adiponectin to endothelin and leptin to insulin. In male but not in female patients, adiponectin to endothelin ratio below 7.0 was associated with Gensini score representing early to high coronary lesions (p = 0.02). In female but not in male patients, leptin to insulin ratio below 3.5 was associated with Gensini score representing early to high coronary lesions (p = 0.013). Conclusion Leptin to insulin and adiponectin to endothelin ratios are novel derived biomarkers useful for noninvasive diagnostics of initial stages of coronary lesions in patients with coronary artery disease."xsd:string
http://purl.uniprot.org/citations/27300270	http://purl.org/dc/terms/identifier	"doi:10.1080/1354750x.2016.1201539"xsd:string
http://purl.uniprot.org/citations/27300270	http://purl.uniprot.org/core/author	"Kots A.Y."xsd:string
http://purl.uniprot.org/citations/27300270	http://purl.uniprot.org/core/author	"Chernushevich O.I."xsd:string
http://purl.uniprot.org/citations/27300270	http://purl.uniprot.org/core/author	"Gavrilova N.E."xsd:string
http://purl.uniprot.org/citations/27300270	http://purl.uniprot.org/core/author	"Gumanova N.G."xsd:string
http://purl.uniprot.org/citations/27300270	http://purl.uniprot.org/core/author	"Metelskaya V.A."xsd:string
http://purl.uniprot.org/citations/27300270	http://purl.uniprot.org/core/date	"2017"xsd:gYear
http://purl.uniprot.org/citations/27300270	http://purl.uniprot.org/core/name	"Biomarkers"xsd:string
http://purl.uniprot.org/citations/27300270	http://purl.uniprot.org/core/pages	"239-245"xsd:string
http://purl.uniprot.org/citations/27300270	http://purl.uniprot.org/core/title	"Ratios of leptin to insulin and adiponectin to endothelin are sex-dependently associated with extent of coronary atherosclerosis."xsd:string
http://purl.uniprot.org/citations/27300270	http://purl.uniprot.org/core/volume	"22"xsd:string
http://purl.uniprot.org/citations/27300270	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/27300270
http://purl.uniprot.org/citations/27300270	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/27300270
http://purl.uniprot.org/uniprot/#_A8K660-mappedCitation-27300270	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/27300270
http://purl.uniprot.org/uniprot/#_A0A9E9AQX1-mappedCitation-27300270	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/27300270
http://purl.uniprot.org/uniprot/#_B2R8Y2-mappedCitation-27300270	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/27300270
http://purl.uniprot.org/uniprot/#_A6XGL2-mappedCitation-27300270	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/27300270
http://purl.uniprot.org/uniprot/#_B2R773-mappedCitation-27300270	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/27300270
http://purl.uniprot.org/uniprot/#_A4D0Y8-mappedCitation-27300270	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/27300270
http://purl.uniprot.org/uniprot/#_D3HIE0-mappedCitation-27300270	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/27300270
http://purl.uniprot.org/uniprot/#_P05305-mappedCitation-27300270	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/27300270
http://purl.uniprot.org/uniprot/#_F6MZK5-mappedCitation-27300270	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/27300270
http://purl.uniprot.org/uniprot/#_I3WAC9-mappedCitation-27300270	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/27300270