| http://purl.uniprot.org/citations/27304884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27304884 | http://www.w3.org/2000/01/rdf-schema#comment | "Sulforaphane (SFN) and moringin (GMG-ITC) are edible isothiocyanates present as glucosinolate precursors in cruciferous vegetables and in the plant Moringa oleifera respectively, and recognized for their chemopreventive and medicinal properties. In contrast to the well-studied SFN, little is known about the molecular pathways targeted by GMG-ITC. We investigated the ability of GMG-ITC to inhibit essential signaling pathways that are frequently upregulated in cancer and immune disorders, such as JAK/STAT and NF-κB. We report for the first time that, similarly to SFN, GMG-ITC in the nanomolar range suppresses IL-3-induced expression of STAT5 target genes. GMG-ITC, like SFN, does not inhibit STAT5 phosphorylation, suggesting a downstream inhibitory event. Interestingly, treatment with GMG-ITC or SFN had a limited inhibitory effect on IFNα-induced STAT1 and STAT2 activity, indicating that both isothiocyanates differentially target JAK/STAT signaling pathways. Furthermore, we showed that GMG-ITC in the micromolar range is a more potent inhibitor of TNF-induced NF-κB activity than SFN. Finally, using a cellular system mimicking constitutive active STAT5-induced cell transformation, we demonstrated that SFN can reverse the survival and growth advantage mediated by oncogenic STAT5 and triggers cell death, therefore providing experimental evidence of a cancer chemopreventive activity of SFN. This work thus identified STAT5, and to a lesser extent STAT1/STAT2, as novel targets of moringin. It also contributes to a better understanding of the biological activities of the dietary isothiocyanates GMG-ITC and SFN and further supports their apparent beneficial role in the prevention of chronic illnesses such as cancer, inflammatory diseases and immune disorders."xsd:string |
| http://purl.uniprot.org/citations/27304884 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0157430"xsd:string |
| http://purl.uniprot.org/citations/27304884 | http://purl.uniprot.org/core/author | "Iori R."xsd:string |
| http://purl.uniprot.org/citations/27304884 | http://purl.uniprot.org/core/author | "Rascle A."xsd:string |
| http://purl.uniprot.org/citations/27304884 | http://purl.uniprot.org/core/author | "Weigl J."xsd:string |
| http://purl.uniprot.org/citations/27304884 | http://purl.uniprot.org/core/author | "Paolini M."xsd:string |
| http://purl.uniprot.org/citations/27304884 | http://purl.uniprot.org/core/author | "Canistro D."xsd:string |
| http://purl.uniprot.org/citations/27304884 | http://purl.uniprot.org/core/author | "De Nicola G.R."xsd:string |
| http://purl.uniprot.org/citations/27304884 | http://purl.uniprot.org/core/author | "Michl C."xsd:string |
| http://purl.uniprot.org/citations/27304884 | http://purl.uniprot.org/core/author | "Vivarelli F."xsd:string |
| http://purl.uniprot.org/citations/27304884 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27304884 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/27304884 | http://purl.uniprot.org/core/pages | "e0157430"xsd:string |
| http://purl.uniprot.org/citations/27304884 | http://purl.uniprot.org/core/title | "The Chemopreventive Phytochemical Moringin Isolated from Moringa oleifera Seeds Inhibits JAK/STAT Signaling."xsd:string |
| http://purl.uniprot.org/citations/27304884 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/27304884 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27304884 |
| http://purl.uniprot.org/citations/27304884 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27304884 |
| http://purl.uniprot.org/uniprot/#_A0A0A0N0M2-mappedCitation-27304884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27304884 |
| http://purl.uniprot.org/uniprot/#_P52630-mappedCitation-27304884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27304884 |
| http://purl.uniprot.org/uniprot/#_A0A8V8TPQ9-mappedCitation-27304884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27304884 |
| http://purl.uniprot.org/uniprot/#_A0A510GDC6-mappedCitation-27304884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27304884 |
| http://purl.uniprot.org/uniprot/#_A5D905-mappedCitation-27304884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27304884 |
| http://purl.uniprot.org/uniprot/#_A0JLQ9-mappedCitation-27304884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27304884 |
| http://purl.uniprot.org/uniprot/#_D2KFR9-mappedCitation-27304884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27304884 |