| http://purl.uniprot.org/citations/27306458 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27306458 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27306458 | http://www.w3.org/2000/01/rdf-schema#comment | "Xpo4 is a bidirectional nuclear transport receptor that mediates nuclear export of eIF5A and Smad3 as well as import of Sox2 and SRY. How Xpo4 recognizes such a variety of cargoes is as yet unknown. Here we present the crystal structure of the RanGTP·Xpo4·eIF5A export complex at 3.2 Å resolution. Xpo4 has a similar structure as CRM1, but the NES-binding site is occluded, and a new interaction site evolved that recognizes both globular domains of eIF5A. eIF5A contains hypusine, a unique amino acid with two positive charges, which is essential for cell viability and eIF5A function in translation. The hypusine docks into a deep, acidic pocket of Xpo4 and is thus a critical element of eIF5A's complex export signature. This further suggests that Xpo4 recognizes other cargoes differently, and illustrates how Xpo4 suppresses - in a chaperone-like manner - undesired interactions of eIF5A inside nuclei."xsd:string |
| http://purl.uniprot.org/citations/27306458 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms11952"xsd:string |
| http://purl.uniprot.org/citations/27306458 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms11952"xsd:string |
| http://purl.uniprot.org/citations/27306458 | http://purl.uniprot.org/core/author | "Goerlich D."xsd:string |
| http://purl.uniprot.org/citations/27306458 | http://purl.uniprot.org/core/author | "Goerlich D."xsd:string |
| http://purl.uniprot.org/citations/27306458 | http://purl.uniprot.org/core/author | "Trakhanov S."xsd:string |
| http://purl.uniprot.org/citations/27306458 | http://purl.uniprot.org/core/author | "Trakhanov S."xsd:string |
| http://purl.uniprot.org/citations/27306458 | http://purl.uniprot.org/core/author | "Aksu M."xsd:string |
| http://purl.uniprot.org/citations/27306458 | http://purl.uniprot.org/core/author | "Aksu M."xsd:string |
| http://purl.uniprot.org/citations/27306458 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27306458 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27306458 | http://purl.uniprot.org/core/name | "Nat. Commun."xsd:string |
| http://purl.uniprot.org/citations/27306458 | http://purl.uniprot.org/core/name | "Nat. Commun."xsd:string |
| http://purl.uniprot.org/citations/27306458 | http://purl.uniprot.org/core/pages | "11952"xsd:string |
| http://purl.uniprot.org/citations/27306458 | http://purl.uniprot.org/core/pages | "11952"xsd:string |
| http://purl.uniprot.org/citations/27306458 | http://purl.uniprot.org/core/title | "Structure of the exportin Xpo4 in complex with RanGTP and the hypusine-containing translation factor eIF5A."xsd:string |
| http://purl.uniprot.org/citations/27306458 | http://purl.uniprot.org/core/title | "Structure of the exportin Xpo4 in complex with RanGTP and the hypusine-containing translation factor eIF5A."xsd:string |
| http://purl.uniprot.org/citations/27306458 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/27306458 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/27306458 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27306458 |
| http://purl.uniprot.org/citations/27306458 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27306458 |
| http://purl.uniprot.org/citations/27306458 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27306458 |
| http://purl.uniprot.org/citations/27306458 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27306458 |