| http://purl.uniprot.org/citations/27311405 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27311405 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27311405 | http://www.w3.org/2000/01/rdf-schema#comment | "Hyaluronidases (Hyals) are broadly used in medical applications to facilitate the dispersion and/or absorption of fluids or medications. This study reports the isolation, cloning, and industrial-scale recombinant production, purification and full characterization, including X-ray structure determination at 1.45 Å, of an extracellular Hyal from the nonpathogenic bacterium Streptomyces koganeiensis. The recombinant S. koganeiensis Hyal (rHyal_Sk) has a novel bacterial catalytic domain with high enzymatic activity, compared with commercially available Hyals, and is more thermostable and presents higher proteolytic resistance, with activity over a broad pH range. Moreover, rHyal_Sk exhibits remarkable substrate specificity for hyaluronic acid (HA) and poses no risk of animal cross-infection."xsd:string |
| http://purl.uniprot.org/citations/27311405 | http://purl.org/dc/terms/identifier | "doi:10.1002/1873-3468.12258"xsd:string |
| http://purl.uniprot.org/citations/27311405 | http://purl.org/dc/terms/identifier | "doi:10.1002/1873-3468.12258"xsd:string |
| http://purl.uniprot.org/citations/27311405 | http://purl.uniprot.org/core/author | "Gavira J.A."xsd:string |
| http://purl.uniprot.org/citations/27311405 | http://purl.uniprot.org/core/author | "Gavira J.A."xsd:string |
| http://purl.uniprot.org/citations/27311405 | http://purl.uniprot.org/core/author | "Pineda-Molina E."xsd:string |
| http://purl.uniprot.org/citations/27311405 | http://purl.uniprot.org/core/author | "Pineda-Molina E."xsd:string |
| http://purl.uniprot.org/citations/27311405 | http://purl.uniprot.org/core/author | "Messina L."xsd:string |
| http://purl.uniprot.org/citations/27311405 | http://purl.uniprot.org/core/author | "Messina L."xsd:string |
| http://purl.uniprot.org/citations/27311405 | http://purl.uniprot.org/core/author | "Pontillo A."xsd:string |
| http://purl.uniprot.org/citations/27311405 | http://purl.uniprot.org/core/author | "Pontillo A."xsd:string |
| http://purl.uniprot.org/citations/27311405 | http://purl.uniprot.org/core/author | "Conejero-Muriel M."xsd:string |
| http://purl.uniprot.org/citations/27311405 | http://purl.uniprot.org/core/author | "Conejero-Muriel M."xsd:string |
| http://purl.uniprot.org/citations/27311405 | http://purl.uniprot.org/core/author | "Musumeci L."xsd:string |
| http://purl.uniprot.org/citations/27311405 | http://purl.uniprot.org/core/author | "Musumeci L."xsd:string |
| http://purl.uniprot.org/citations/27311405 | http://purl.uniprot.org/core/author | "Caruso S."xsd:string |
| http://purl.uniprot.org/citations/27311405 | http://purl.uniprot.org/core/author | "Caruso S."xsd:string |
| http://purl.uniprot.org/citations/27311405 | http://purl.uniprot.org/core/author | "Di Pasquale R."xsd:string |
| http://purl.uniprot.org/citations/27311405 | http://purl.uniprot.org/core/author | "Di Pasquale R."xsd:string |
| http://purl.uniprot.org/citations/27311405 | http://purl.uniprot.org/core/author | "Diaz-Mochon J.J."xsd:string |
| http://purl.uniprot.org/citations/27311405 | http://purl.uniprot.org/core/author | "Diaz-Mochon J.J."xsd:string |
| http://purl.uniprot.org/citations/27311405 | http://purl.uniprot.org/core/author | "Pavan M."xsd:string |
| http://purl.uniprot.org/citations/27311405 | http://purl.uniprot.org/core/author | "Pavan M."xsd:string |