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http://purl.uniprot.org/citations/27314815http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/27314815http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/27314815http://www.w3.org/2000/01/rdf-schema#comment"Scorpine-like peptides are two domain peptides found in different scorpion venoms displaying various antimicrobial, cytolytic, and potassium channel-blocking activities. The relative contribution of each domain to their different activities remains to be elucidated. Here, we report the recombinant production, solution structure, and antiparasitic activity of Hge36, first identified as a naturally occurring truncated form of a Scorpine-like peptide from the venom of Hoffmannihadrurus gertschi. We also show that removing the first four residues from Hge36 renders a molecule with enhanced potassium channel-blocking and antiparasitic activities. Our results are important to rationalize the structure-function relationships of a pharmacologically versatile molecular scaffold."xsd:string
http://purl.uniprot.org/citations/27314815http://purl.org/dc/terms/identifier"doi:10.1002/1873-3468.12255"xsd:string
http://purl.uniprot.org/citations/27314815http://purl.org/dc/terms/identifier"doi:10.1002/1873-3468.12255"xsd:string
http://purl.uniprot.org/citations/27314815http://purl.uniprot.org/core/author"Rodriguez de la Vega R.C."xsd:string
http://purl.uniprot.org/citations/27314815http://purl.uniprot.org/core/author"Rodriguez de la Vega R.C."xsd:string
http://purl.uniprot.org/citations/27314815http://purl.uniprot.org/core/author"Landa A."xsd:string
http://purl.uniprot.org/citations/27314815http://purl.uniprot.org/core/author"Landa A."xsd:string
http://purl.uniprot.org/citations/27314815http://purl.uniprot.org/core/author"Del Rio-Portilla F."xsd:string
http://purl.uniprot.org/citations/27314815http://purl.uniprot.org/core/author"Del Rio-Portilla F."xsd:string
http://purl.uniprot.org/citations/27314815http://purl.uniprot.org/core/author"Flores-Solis D."xsd:string
http://purl.uniprot.org/citations/27314815http://purl.uniprot.org/core/author"Flores-Solis D."xsd:string
http://purl.uniprot.org/citations/27314815http://purl.uniprot.org/core/author"Cano-Sanchez P."xsd:string
http://purl.uniprot.org/citations/27314815http://purl.uniprot.org/core/author"Cano-Sanchez P."xsd:string
http://purl.uniprot.org/citations/27314815http://purl.uniprot.org/core/author"Ramirez-Cordero B.E."xsd:string
http://purl.uniprot.org/citations/27314815http://purl.uniprot.org/core/author"Ramirez-Cordero B.E."xsd:string
http://purl.uniprot.org/citations/27314815http://purl.uniprot.org/core/author"Rodriguez-Lima O."xsd:string
http://purl.uniprot.org/citations/27314815http://purl.uniprot.org/core/author"Rodriguez-Lima O."xsd:string
http://purl.uniprot.org/citations/27314815http://purl.uniprot.org/core/author"Toledano Y."xsd:string
http://purl.uniprot.org/citations/27314815http://purl.uniprot.org/core/author"Toledano Y."xsd:string
http://purl.uniprot.org/citations/27314815http://purl.uniprot.org/core/date"2016"xsd:gYear
http://purl.uniprot.org/citations/27314815http://purl.uniprot.org/core/date"2016"xsd:gYear
http://purl.uniprot.org/citations/27314815http://purl.uniprot.org/core/name"FEBS Lett."xsd:string
http://purl.uniprot.org/citations/27314815http://purl.uniprot.org/core/name"FEBS Lett."xsd:string