| http://purl.uniprot.org/citations/27318131 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27318131 | http://www.w3.org/2000/01/rdf-schema#comment | "Immune-activated microglia from aged mice produce exaggerated levels of cytokines. Despite high levels of microglial interleukin (IL)-10 in the aged brain, neuroinflammation was prolonged and associated with depressive-like deficits. Because astrocytes respond to IL-10 and, in turn, attenuate microglial activation, we investigated if astrocyte-mediated resolution of microglial activation was impaired with age. Here, aged astrocytes had a dysfunctional profile with higher glial fibrillary acidic protein, lower glutamate transporter expression, and significant cytoskeletal re-arrangement. Moreover, aged astrocytes had reduced expression of growth factors and IL-10 receptor-1 (IL-10R1). After in vivo lipopolysaccharide immune challenge, aged astrocytes had a molecular signature associated with reduced responsiveness to IL-10. This IL-10 insensitivity of aged astrocytes resulted in a failure to induce IL-10R1 and transforming growth factor β and resolve microglial activation. In addition, adult astrocytes reduced microglial activation when co-cultured ex vivo, whereas aged astrocytes did not. Consistent with the aging studies, IL-10R(KO) astrocytes did not augment transforming growth factor β after immune challenge and failed to resolve microglial activation. Collectively, a major cytokine-regulatory loop between activated microglia and astrocytes is impaired in the aged brain."xsd:string |
| http://purl.uniprot.org/citations/27318131 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neurobiolaging.2016.04.014"xsd:string |
| http://purl.uniprot.org/citations/27318131 | http://purl.uniprot.org/core/author | "Godbout J.P."xsd:string |
| http://purl.uniprot.org/citations/27318131 | http://purl.uniprot.org/core/author | "Walker F.R."xsd:string |
| http://purl.uniprot.org/citations/27318131 | http://purl.uniprot.org/core/author | "Norden D.M."xsd:string |
| http://purl.uniprot.org/citations/27318131 | http://purl.uniprot.org/core/author | "Trojanowski P.J."xsd:string |
| http://purl.uniprot.org/citations/27318131 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27318131 | http://purl.uniprot.org/core/name | "Neurobiol Aging"xsd:string |
| http://purl.uniprot.org/citations/27318131 | http://purl.uniprot.org/core/pages | "22-41"xsd:string |
| http://purl.uniprot.org/citations/27318131 | http://purl.uniprot.org/core/title | "Insensitivity of astrocytes to interleukin 10 signaling following peripheral immune challenge results in prolonged microglial activation in the aged brain."xsd:string |
| http://purl.uniprot.org/citations/27318131 | http://purl.uniprot.org/core/volume | "44"xsd:string |
| http://purl.uniprot.org/citations/27318131 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27318131 |
| http://purl.uniprot.org/citations/27318131 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27318131 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWC8-mappedCitation-27318131 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27318131 |
| http://purl.uniprot.org/uniprot/#_A0A087WQM2-mappedCitation-27318131 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27318131 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RNW1-mappedCitation-27318131 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27318131 |
| http://purl.uniprot.org/uniprot/#_D3YW23-mappedCitation-27318131 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27318131 |
| http://purl.uniprot.org/uniprot/#_D3YXL4-mappedCitation-27318131 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27318131 |
| http://purl.uniprot.org/uniprot/#_E0CZD1-mappedCitation-27318131 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27318131 |
| http://purl.uniprot.org/uniprot/#_E9Q083-mappedCitation-27318131 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27318131 |
| http://purl.uniprot.org/uniprot/#_E9Q6I6-mappedCitation-27318131 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27318131 |
| http://purl.uniprot.org/uniprot/#_P14097-mappedCitation-27318131 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27318131 |
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| http://purl.uniprot.org/uniprot/#_A2CG45-mappedCitation-27318131 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27318131 |