| http://purl.uniprot.org/citations/27320770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27320770 | http://www.w3.org/2000/01/rdf-schema#comment | "Systemic lupus erythematosus (SLE) is a disease characterized by excessive proinflammatory cytokine production and damage to multiple organ systems. To investigate the potential association between cytokine gene polymorphisms and SLE, we performed a case-control study based on Polish population. SLE patients and controls, were examined for IL-23A rs11171806 G/A and IL-23R (rs1884444 G/T, rs10489629 G/A) by TaqMan SNP genotyping assay, for IL-17F rs763780 A/G and rs2397084A/G using the PCR-RFLP method. An increased frequency of AG genotype as well as G allele of the IL-17F rs763780 was found in patients with SLE, as compared with healthy subjects (OR = 3.947; p = 0.001 and OR = 3.538; p = 0.002, respectively). Frequencies of the rs1884444 TT genotype (OR = 138.1) and the rs1884444 T allele (OR = 2.176) were also higher in SLE patients (both p < 0.0001). Overall, weak LD was observed between the IL-17F rs763780 A/G and rs2397084 A/G polymorphisms (D'-0.003, r2 - 0.000). From four possible haplotypes, frequencies of AG showed differences between both examined groups (p < 0.0001). We also observed a weak LD between the IL-23R rs10489629G/A and rs1884444 G/T (D'-0.199, r2 -0.026). The genotype-phenotype analysis showed significant association between the IL-17F rs2397084 and mean value of the hemoglobin (p = 0.01), the IL-17F rs763780 and age (p = 0.008) and lupus anticoagulant (p = 0.09), the IL-23 rs11171806 and urea (p = 0.08) and C3 complement (p = 0.03), and the IL-23R rs1884444 G/T and activated partial thromboplastin time (p = 0.06). Present findings indicated that IL-17F rs763780 A/G and IL-23R rs1884444 G/T polymorphisms may be involved in susceptibility to SLE in the Polish population."xsd:string |
| http://purl.uniprot.org/citations/27320770 | http://purl.org/dc/terms/identifier | "doi:10.1080/08916934.2016.1196678"xsd:string |
| http://purl.uniprot.org/citations/27320770 | http://purl.uniprot.org/core/author | "Sowinska A."xsd:string |
| http://purl.uniprot.org/citations/27320770 | http://purl.uniprot.org/core/author | "Jagodzinski P.P."xsd:string |
| http://purl.uniprot.org/citations/27320770 | http://purl.uniprot.org/core/author | "Piotrowski P."xsd:string |
| http://purl.uniprot.org/citations/27320770 | http://purl.uniprot.org/core/author | "Olesinska M."xsd:string |
| http://purl.uniprot.org/citations/27320770 | http://purl.uniprot.org/core/author | "Paradowska-Gorycka A."xsd:string |
| http://purl.uniprot.org/citations/27320770 | http://purl.uniprot.org/core/author | "Grobelna M.K."xsd:string |
| http://purl.uniprot.org/citations/27320770 | http://purl.uniprot.org/core/author | "Stypinska B."xsd:string |
| http://purl.uniprot.org/citations/27320770 | http://purl.uniprot.org/core/author | "Walczyk M."xsd:string |
| http://purl.uniprot.org/citations/27320770 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27320770 | http://purl.uniprot.org/core/name | "Autoimmunity"xsd:string |
| http://purl.uniprot.org/citations/27320770 | http://purl.uniprot.org/core/pages | "373-382"xsd:string |
| http://purl.uniprot.org/citations/27320770 | http://purl.uniprot.org/core/title | "Impact of the IL-17F, IL-23 and IL-23R on susceptibility and phenotype of systemic lupus erythematosus."xsd:string |
| http://purl.uniprot.org/citations/27320770 | http://purl.uniprot.org/core/volume | "49"xsd:string |
| http://purl.uniprot.org/citations/27320770 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27320770 |
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