| http://purl.uniprot.org/citations/27327535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27327535 | http://www.w3.org/2000/01/rdf-schema#comment | "Solar lentigines are a common feature of sun-induced skin ageing. Little is known, however, about the genetic factors contributing to their development. In this genome-wide association study, we aimed to identify genetic loci associated with solar lentigines on the face in 502 middle-aged French women. Nine SNPs, gathered in two independent blocks on chromosome 6, exhibited a false discovery rate below 25% when looking for associations with the facial lentigine score. The first block, in the 6p22 region, corresponded to intergenic SNPs and also exhibited a significant association with forehead lentigines (P = 1.37 × 10(-8) ). The second block, within the 6p21 HLA region, was associated with decreased HLA-C expression according to several eQTL databases. Interestingly, these SNPs were also in high linkage disequilibrium with the HLA-C*0701 allele (r(2) = 0.95). We replicated an association recently found by GWAS in the IRF4 gene. Finally, a complementary study on 44 selected candidate SNPs revealed novel associations in the MITF gene. Overall, our results point to several mechanisms involved in the severity of facial lentigines, including HLA/immunity and the melanogenesis pathway."xsd:string |
| http://purl.uniprot.org/citations/27327535 | http://purl.org/dc/terms/identifier | "doi:10.1111/pcmr.12502"xsd:string |
| http://purl.uniprot.org/citations/27327535 | http://purl.uniprot.org/core/author | "Zagury J.F."xsd:string |
| http://purl.uniprot.org/citations/27327535 | http://purl.uniprot.org/core/author | "Carpentier W."xsd:string |
| http://purl.uniprot.org/citations/27327535 | http://purl.uniprot.org/core/author | "Tschachler E."xsd:string |
| http://purl.uniprot.org/citations/27327535 | http://purl.uniprot.org/core/author | "Ezzedine K."xsd:string |
| http://purl.uniprot.org/citations/27327535 | http://purl.uniprot.org/core/author | "Hercberg S."xsd:string |
| http://purl.uniprot.org/citations/27327535 | http://purl.uniprot.org/core/author | "Galan P."xsd:string |
| http://purl.uniprot.org/citations/27327535 | http://purl.uniprot.org/core/author | "Malvy D."xsd:string |
| http://purl.uniprot.org/citations/27327535 | http://purl.uniprot.org/core/author | "Coulonges C."xsd:string |
| http://purl.uniprot.org/citations/27327535 | http://purl.uniprot.org/core/author | "Labib T."xsd:string |
| http://purl.uniprot.org/citations/27327535 | http://purl.uniprot.org/core/author | "Taing L."xsd:string |
| http://purl.uniprot.org/citations/27327535 | http://purl.uniprot.org/core/author | "Latreille J."xsd:string |
| http://purl.uniprot.org/citations/27327535 | http://purl.uniprot.org/core/author | "Jdid R."xsd:string |
| http://purl.uniprot.org/citations/27327535 | http://purl.uniprot.org/core/author | "Morizot F."xsd:string |
| http://purl.uniprot.org/citations/27327535 | http://purl.uniprot.org/core/author | "Laville V."xsd:string |
| http://purl.uniprot.org/citations/27327535 | http://purl.uniprot.org/core/author | "Ulveling D."xsd:string |
| http://purl.uniprot.org/citations/27327535 | http://purl.uniprot.org/core/author | "Clerc S.L."xsd:string |
| http://purl.uniprot.org/citations/27327535 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27327535 | http://purl.uniprot.org/core/name | "Pigment Cell Melanoma Res"xsd:string |
| http://purl.uniprot.org/citations/27327535 | http://purl.uniprot.org/core/pages | "550-558"xsd:string |
| http://purl.uniprot.org/citations/27327535 | http://purl.uniprot.org/core/title | "A genome-wide association study in Caucasian women suggests the involvement of HLA genes in the severity of facial solar lentigines."xsd:string |
| http://purl.uniprot.org/citations/27327535 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/27327535 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27327535 |