http://purl.uniprot.org/citations/27345620 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/27345620 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundCutaneous T-cell lymphomas (CTCL) are skin malignancies including mycosis fungoides (MF) and CD30(+) lymphoproliferative disorders (LPD). In early disease, CTCL can be difficult to diagnose, especially in MF for which there is no reliable diagnostic marker. MF/CTCL have increased expression of thymocyte selection-associated HMG box protein (TOX). Although TOX has been proposed to be a diagnostic marker for MF, further validation studies are needed. Moreover, it is unclear what drives TOX expression or its role in MF/CTCL.ObjectiveWe hypothesize evaluation of TOX levels across a spectrum of CTCL, including MF precursor (large plaque parapsoriasis, LPP), will help elucidate the implications of altered TOX expression.Materials and methodsTOX staining was performed in MF, CD30(+) LPD, LPP as well as benign inflammatory dermatoses (BID) and normal skin (NS). CTCL cell lines were utilized to evaluate the regulation of TOX.ResultsPositive TOX expression was identified in 73.6% of MF cases and in 31.6% of BID/NS. TOX had a positive predictive value (PPV) for MF of 86.7% and a negative predictive value (NPV) of 48.1%. TOX expression in MF was detected more commonly in Black patients (P = 0.015) and less commonly in transformed MF (P = 0.045). LPP had positive TOX staining in 70.0%. In CTCL cells, GATA3 knockdown decreased TOX mRNA and protein expression. TOX expression also decreased in the presence of CTCL therapeutics.ConclusionOur data indicate that TOX is useful as a diagnostic marker in MF. Moreover, TOX expression was evident in LPP, indicating it may have a previously unappreciated role in the development of MF. Finally, our data suggest that GATA3 regulates TOX, revealing insight into TOX regulation."xsd:string |
http://purl.uniprot.org/citations/27345620 | http://purl.org/dc/terms/identifier | "doi:10.1111/jdv.13651"xsd:string |
http://purl.uniprot.org/citations/27345620 | http://purl.uniprot.org/core/author | "Eischen C.M."xsd:string |
http://purl.uniprot.org/citations/27345620 | http://purl.uniprot.org/core/author | "Zwerner J.P."xsd:string |
http://purl.uniprot.org/citations/27345620 | http://purl.uniprot.org/core/author | "McGirt L.Y."xsd:string |
http://purl.uniprot.org/citations/27345620 | http://purl.uniprot.org/core/author | "Johnson V.E."xsd:string |
http://purl.uniprot.org/citations/27345620 | http://purl.uniprot.org/core/author | "Zic J.A."xsd:string |
http://purl.uniprot.org/citations/27345620 | http://purl.uniprot.org/core/author | "Degesys C.A."xsd:string |
http://purl.uniprot.org/citations/27345620 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
http://purl.uniprot.org/citations/27345620 | http://purl.uniprot.org/core/name | "J Eur Acad Dermatol Venereol"xsd:string |
http://purl.uniprot.org/citations/27345620 | http://purl.uniprot.org/core/pages | "1497-1502"xsd:string |
http://purl.uniprot.org/citations/27345620 | http://purl.uniprot.org/core/title | "TOX expression and role in CTCL."xsd:string |
http://purl.uniprot.org/citations/27345620 | http://purl.uniprot.org/core/volume | "30"xsd:string |
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