| http://purl.uniprot.org/citations/27349290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27349290 | http://www.w3.org/2000/01/rdf-schema#comment | "Nitric oxide (NO) markedly induces cardiomyocyte (CM) differentiation of embryonic stem (ES) cells. Here we examined the role of the Ca(2+) signaling in the NO-induced CM differentiation of mouse ES cells. We found that NO induced intracellular Ca(2+) increases in ES cells in a dose-dependent manner, and application of IP3 pathway antagonists not only significantly inhibited this induced Ca(2+) increase but also abolished NO-induced CM differentiation of ES cells. Subsequently, all 3 types of inositol 1, 4, 5-trisphosphate (IP3) receptors (IP3Rs) in mouse ES cells were individually or triply knocked down. Interestingly, only knockdown of type 3 IP3R (IP3R3) or triple-knockdown of three types of IP3Rs significantly inhibited the NO-induced Ca(2+) increases. Consistently, IP3R3 knockdown blocked the NO-induced CM differentiation of ES cells. CMs derived from IP3R3 knockdown ES cells also showed both structural and functional defects. In summary, our results indicate that the IP3R3-Ca(2+) pathway is required for NO-induced CM differentiation of ES cells."xsd:string |
| http://purl.uniprot.org/citations/27349290 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2016.06.016"xsd:string |
| http://purl.uniprot.org/citations/27349290 | http://purl.uniprot.org/core/author | "Huang W."xsd:string |
| http://purl.uniprot.org/citations/27349290 | http://purl.uniprot.org/core/author | "Wei W."xsd:string |
| http://purl.uniprot.org/citations/27349290 | http://purl.uniprot.org/core/author | "Yue J."xsd:string |
| http://purl.uniprot.org/citations/27349290 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27349290 | http://purl.uniprot.org/core/name | "Exp Cell Res"xsd:string |
| http://purl.uniprot.org/citations/27349290 | http://purl.uniprot.org/core/pages | "9-16"xsd:string |
| http://purl.uniprot.org/citations/27349290 | http://purl.uniprot.org/core/title | "Requirement of IP3 receptor 3 (IP3R3) in nitric oxide induced cardiomyocyte differentiation of mouse embryonic stem cells."xsd:string |
| http://purl.uniprot.org/citations/27349290 | http://purl.uniprot.org/core/volume | "346"xsd:string |
| http://purl.uniprot.org/citations/27349290 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27349290 |
| http://purl.uniprot.org/citations/27349290 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27349290 |
| http://purl.uniprot.org/uniprot/#_Q0IJ80-mappedCitation-27349290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27349290 |
| http://purl.uniprot.org/uniprot/#_Q922U9-mappedCitation-27349290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27349290 |
| http://purl.uniprot.org/uniprot/#_P70227-mappedCitation-27349290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27349290 |
| http://purl.uniprot.org/uniprot/Q922U9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27349290 |
| http://purl.uniprot.org/uniprot/Q0IJ80 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27349290 |
| http://purl.uniprot.org/uniprot/P70227 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27349290 |