| http://purl.uniprot.org/citations/27350307 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27350307 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent studies suggest that aberrant expression of miR-24 is linked to various human cancers, including tongue squamous cell carcinoma (TSCC). F-box and WD-40 domain protein 7 (FBXW7), a tumor-suppressor gene, is responsible for the degradation of several proto-oncogenes. However, the function and mechanism of miR-24 and FBXW7 in TSCC remains unclear. In the present study, we found that miR-24 was increased in TSCC tissues and cell lines, and that upregulation of miR-24 was associated with advanced clinical stage and a shorter overall survival of TSCC patients. Inhibition of miR-24 significantly suppressed the proliferation, migration and invasion of TSCC cells in vitro. Furthermore, miR-24 repressed FBXW7 expression by directly binding to the 3-untranslated region of FBXW7. Moreover, the suppression of FBXW7 increased the proliferation, migration and invasion of TSCC cells, and the restoration of FBXW7 substantially attenuated the oncogenic effects of miR-24. In conclusion, our results demonstrated that upregulation of miR-24 was associated with tumor progression and poor prognosis in TSCC patients, and that overexpression of miR-24 was correlated with the proliferation, migration and invasion of TSCC cells in vitro, at least partially through regulation of its functional target FBXW7. Thus, miR-24 may serve as a novel potential biomarker for the prognosis of TSCC patients."xsd:string |
| http://purl.uniprot.org/citations/27350307 | http://purl.org/dc/terms/identifier | "doi:10.3892/or.2016.4891"xsd:string |
| http://purl.uniprot.org/citations/27350307 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/27350307 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/27350307 | http://purl.uniprot.org/core/author | "Li D."xsd:string |
| http://purl.uniprot.org/citations/27350307 | http://purl.uniprot.org/core/author | "Peng C."xsd:string |
| http://purl.uniprot.org/citations/27350307 | http://purl.uniprot.org/core/author | "Gao M."xsd:string |
| http://purl.uniprot.org/citations/27350307 | http://purl.uniprot.org/core/author | "Yu Y."xsd:string |
| http://purl.uniprot.org/citations/27350307 | http://purl.uniprot.org/core/author | "Zhao J."xsd:string |
| http://purl.uniprot.org/citations/27350307 | http://purl.uniprot.org/core/author | "Zheng X."xsd:string |
| http://purl.uniprot.org/citations/27350307 | http://purl.uniprot.org/core/author | "Hu C."xsd:string |
| http://purl.uniprot.org/citations/27350307 | http://purl.uniprot.org/core/author | "Chi J."xsd:string |
| http://purl.uniprot.org/citations/27350307 | http://purl.uniprot.org/core/author | "Yun X."xsd:string |
| http://purl.uniprot.org/citations/27350307 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27350307 | http://purl.uniprot.org/core/name | "Oncol Rep"xsd:string |
| http://purl.uniprot.org/citations/27350307 | http://purl.uniprot.org/core/pages | "1143-1149"xsd:string |
| http://purl.uniprot.org/citations/27350307 | http://purl.uniprot.org/core/title | "miR-24 promotes the proliferation, migration and invasion in human tongue squamous cell carcinoma by targeting FBXW7."xsd:string |
| http://purl.uniprot.org/citations/27350307 | http://purl.uniprot.org/core/volume | "36"xsd:string |
| http://purl.uniprot.org/citations/27350307 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27350307 |
| http://purl.uniprot.org/citations/27350307 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27350307 |
| http://purl.uniprot.org/uniprot/#_G0Z2K0-mappedCitation-27350307 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27350307 |
| http://purl.uniprot.org/uniprot/#_A7BJS8-mappedCitation-27350307 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27350307 |
| http://purl.uniprot.org/uniprot/#_B7Z2C8-mappedCitation-27350307 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27350307 |
| http://purl.uniprot.org/uniprot/#_B7Z623-mappedCitation-27350307 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27350307 |