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http://purl.uniprot.org/citations/27353797http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/27353797http://www.w3.org/2000/01/rdf-schema#comment"

Context

Carbon monoxide (CO) poisoning results in neuronal injury. The expression of Dickkopf-1 (DKK-1) has not been investigated previously after CO poisoning.

Objective

The current study aimed to investigate the DKK-1 expression levels in humans and rats with acute CO poisoning and to analyze their correlation with poisoning severity.

Materials and methods

We measured serum DKK-1 levels in patients with acute CO poisoning (n = 94) and in healthy controls (n = 90). On admission, a poisoning severity score (PSS) was determined for each patient. In addition, 36 male Sprague-Dawley rats were randomly assigned into three groups: (a) Sham group, (b) Low CO group and (c) High CO group. At 2 h after CO poisoning, DKK-1 expression and histopathological damage in the hippocampal tissues were measured.

Results

Serum DKK-1 levels were significantly higher in the acute CO-poisoned patients, compared to the healthy controls. Serum DKK-1 levels were significantly higher in the CO-poisoned patients with a lower PSS. In rats, CO poisoning induced significant upregulation of the gene and protein expression of DKK-1 in hippocampal tissues. Moreover, there was a positive correlation between DKK-1 levels and the degree of damage in the hippocampal tissues.

Discussion

DKK-1 induction in neurons after CO poisoning causes further neuronal injury. The severity of acute CO poisoning in rat models is associated with elevated serum DKK-1 levels and its upregulation in the brain tissue.

Conclusion

DKK-1 appears to have potential utility in providing valuable information for determining the severity and damage of CO poisoning."xsd:string
http://purl.uniprot.org/citations/27353797http://purl.org/dc/terms/identifier"doi:10.1080/08958378.2016.1198440"xsd:string
http://purl.uniprot.org/citations/27353797http://purl.uniprot.org/core/author"Wang D."xsd:string
http://purl.uniprot.org/citations/27353797http://purl.uniprot.org/core/author"Zhang N."xsd:string
http://purl.uniprot.org/citations/27353797http://purl.uniprot.org/core/author"Xing J."xsd:string
http://purl.uniprot.org/citations/27353797http://purl.uniprot.org/core/author"Dong N."xsd:string
http://purl.uniprot.org/citations/27353797http://purl.uniprot.org/core/author"Pang L."xsd:string
http://purl.uniprot.org/citations/27353797http://purl.uniprot.org/core/date"2016"xsd:gYear
http://purl.uniprot.org/citations/27353797http://purl.uniprot.org/core/name"Inhal Toxicol"xsd:string
http://purl.uniprot.org/citations/27353797http://purl.uniprot.org/core/pages"455-462"xsd:string
http://purl.uniprot.org/citations/27353797http://purl.uniprot.org/core/title"Increased Dickkopf-1 expression is correlated with poisoning severity in carbon monoxide-poisoned humans and rats."xsd:string
http://purl.uniprot.org/citations/27353797http://purl.uniprot.org/core/volume"28"xsd:string
http://purl.uniprot.org/citations/27353797http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/27353797
http://purl.uniprot.org/citations/27353797http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/27353797
http://purl.uniprot.org/uniprot/#_I1W660-mappedCitation-27353797http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27353797
http://purl.uniprot.org/uniprot/#_O94907-mappedCitation-27353797http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27353797
http://purl.uniprot.org/uniprot/I1W660http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/27353797
http://purl.uniprot.org/uniprot/O94907http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/27353797