| http://purl.uniprot.org/citations/27356472 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27356472 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27356472 | http://www.w3.org/2000/01/rdf-schema#comment | "Transcriptional plasticity is a major driver of phenotypic differences between species. The lower temperature limit (LTL), namely the lower end of survival temperature, is an important trait delimiting the geographical distribution of a species, however, the genetic mechanisms are poorly understood. We investigated the inter-species transcriptional diversification in cold responses between zebrafish Danio rerio and tilapia Oreochromis niloticus, which were reared at a common temperature (28 °C) but have distinct LTLs. We identified significant expressional divergence between the two species in the orthologous genes from gills when the temperature cooled to the LTL of tilapia (8 °C). Five KEGG pathways were found sequentially over-represented in the zebrafish/tilapia divergently expressed genes in the duration (12 hour) of 8 °C exposure, forming a signaling cascade from metabolic regulation to apoptosis via FoxO signaling. Consistently, we found differential progression of apoptosis in the gills of the two species in which zebrafish manifested a delayed and milder apoptotic phenotype than tilapia, corresponding with a lower LTL of zebrafish. We identified diverged expression in 25 apoptosis-related transcription factors between the two species which forms an interacting network with diverged factors involving the FoxO signaling and metabolic regulation. We propose a genetic network which regulates LTL in fishes."xsd:string |
| http://purl.uniprot.org/citations/27356472 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep28952"xsd:string |
| http://purl.uniprot.org/citations/27356472 | http://purl.uniprot.org/core/author | "Chen L."xsd:string |
| http://purl.uniprot.org/citations/27356472 | http://purl.uniprot.org/core/author | "Chen L."xsd:string |
| http://purl.uniprot.org/citations/27356472 | http://purl.uniprot.org/core/author | "Hu P."xsd:string |
| http://purl.uniprot.org/citations/27356472 | http://purl.uniprot.org/core/author | "Hu P."xsd:string |
| http://purl.uniprot.org/citations/27356472 | http://purl.uniprot.org/core/author | "Han B."xsd:string |
| http://purl.uniprot.org/citations/27356472 | http://purl.uniprot.org/core/author | "Han B."xsd:string |
| http://purl.uniprot.org/citations/27356472 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/27356472 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/27356472 | http://purl.uniprot.org/core/author | "Jiang S."xsd:string |
| http://purl.uniprot.org/citations/27356472 | http://purl.uniprot.org/core/author | "Jiang S."xsd:string |
| http://purl.uniprot.org/citations/27356472 | http://purl.uniprot.org/core/author | "Liu M."xsd:string |
| http://purl.uniprot.org/citations/27356472 | http://purl.uniprot.org/core/author | "Liu M."xsd:string |
| http://purl.uniprot.org/citations/27356472 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/27356472 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/27356472 | http://purl.uniprot.org/core/author | "Niu H."xsd:string |
| http://purl.uniprot.org/citations/27356472 | http://purl.uniprot.org/core/author | "Niu H."xsd:string |
| http://purl.uniprot.org/citations/27356472 | http://purl.uniprot.org/core/author | "Xu Q."xsd:string |
| http://purl.uniprot.org/citations/27356472 | http://purl.uniprot.org/core/author | "Xu Q."xsd:string |
| http://purl.uniprot.org/citations/27356472 | http://purl.uniprot.org/core/author | "Wang J.'"xsd:string |
| http://purl.uniprot.org/citations/27356472 | http://purl.uniprot.org/core/author | "Wang J.'"xsd:string |
| http://purl.uniprot.org/citations/27356472 | http://purl.uniprot.org/core/author | "Zhang D."xsd:string |