| http://purl.uniprot.org/citations/27363391 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27363391 | http://www.w3.org/2000/01/rdf-schema#comment | "This study investigated the function of a chloride channel blocker, DIDS. Both in vitro and in vivo studies found that DIDS significantly inhibits lipopolysaccharide (LPS)-induced release of proin flammatory cytokines. Here, we show that DIDS inhibits LPS-induced inflammation, as shown by downregulation of inflammatory cytokines via inhibition of the TLR4/NF-κB pathway. Furthermore, we show that ClC-3siRNA transfection reduces LPS-induced pro-inflammation in Raw264.7 cells, indicating that ClC-3 is involved in the inhibitory effect of DIDS during LPS-induced cytokines release. In vivo, DIDS reduced LPS-induced mortality, decreased LPS-induced organic damage, and down-regulated LPS-induced expression of inflammatory cytokines. In sum, we demonstrate that ClC-3 is a pro-inflammatory factor and that inhibition of ClC-3 inhibits inflammatory induction both in vitro and in vivo, suggesting that ClC-3 is a potential anti-inflammatory target."xsd:string |
| http://purl.uniprot.org/citations/27363391 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep27583"xsd:string |
| http://purl.uniprot.org/citations/27363391 | http://purl.uniprot.org/core/author | "Huang Y.W."xsd:string |
| http://purl.uniprot.org/citations/27363391 | http://purl.uniprot.org/core/author | "Lin X."xsd:string |
| http://purl.uniprot.org/citations/27363391 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/27363391 | http://purl.uniprot.org/core/author | "Wu Z."xsd:string |
| http://purl.uniprot.org/citations/27363391 | http://purl.uniprot.org/core/author | "Zhang J.H."xsd:string |
| http://purl.uniprot.org/citations/27363391 | http://purl.uniprot.org/core/author | "Liao Y.J."xsd:string |
| http://purl.uniprot.org/citations/27363391 | http://purl.uniprot.org/core/author | "Bai Z.Q."xsd:string |
| http://purl.uniprot.org/citations/27363391 | http://purl.uniprot.org/core/author | "Xiang N.L."xsd:string |
| http://purl.uniprot.org/citations/27363391 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27363391 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/27363391 | http://purl.uniprot.org/core/pages | "27583"xsd:string |
| http://purl.uniprot.org/citations/27363391 | http://purl.uniprot.org/core/title | "Abrogating ClC-3 Inhibits LPS-induced Inflammation via Blocking the TLR4/NF-kappaB Pathway."xsd:string |
| http://purl.uniprot.org/citations/27363391 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/27363391 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27363391 |
| http://purl.uniprot.org/citations/27363391 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27363391 |
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