| http://purl.uniprot.org/citations/27373149 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27373149 | http://www.w3.org/2000/01/rdf-schema#comment | "Loss of the genome maintenance factor Elg1 causes serious genome instability that leads to cancer, but the underlying mechanism is unknown. Elg1 forms the major subunit of a replication factor C-like complex, Elg1-RLC, which unloads the ring-shaped polymerase clamp PCNA from DNA during replication. Here, we show that prolonged retention of PCNA on DNA into G2/M phase is the major cause of genome instability in elg1Δ yeast. Overexpression-induced accumulation of PCNA on DNA causes genome instability. Conversely, disassembly-prone PCNA mutants that relieve PCNA accumulation rescue the genome instability of elg1Δ cells. Covalent modifications to the retained PCNA make only a minor contribution to elg1Δ genome instability. By engineering cell-cycle-regulated ELG1 alleles, we show that abnormal accumulation of PCNA on DNA during S phase causes moderate genome instability and its retention through G2/M phase exacerbates genome instability. Our results reveal that PCNA unloading by Elg1-RLC is critical for genome maintenance."xsd:string |
| http://purl.uniprot.org/citations/27373149 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2016.06.030"xsd:string |
| http://purl.uniprot.org/citations/27373149 | http://purl.uniprot.org/core/author | "Johnson C."xsd:string |
| http://purl.uniprot.org/citations/27373149 | http://purl.uniprot.org/core/author | "Kubota T."xsd:string |
| http://purl.uniprot.org/citations/27373149 | http://purl.uniprot.org/core/author | "Takahashi T.S."xsd:string |
| http://purl.uniprot.org/citations/27373149 | http://purl.uniprot.org/core/author | "Gali V.K."xsd:string |
| http://purl.uniprot.org/citations/27373149 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27373149 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/27373149 | http://purl.uniprot.org/core/pages | "684-695"xsd:string |
| http://purl.uniprot.org/citations/27373149 | http://purl.uniprot.org/core/title | "PCNA Retention on DNA into G2/M Phase Causes Genome Instability in Cells Lacking Elg1."xsd:string |
| http://purl.uniprot.org/citations/27373149 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/27373149 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27373149 |
| http://purl.uniprot.org/citations/27373149 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27373149 |
| http://purl.uniprot.org/uniprot/#_P15873-mappedCitation-27373149 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27373149 |
| http://purl.uniprot.org/uniprot/#_Q12050-mappedCitation-27373149 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27373149 |
| http://purl.uniprot.org/uniprot/P15873 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27373149 |
| http://purl.uniprot.org/uniprot/Q12050 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27373149 |