| http://purl.uniprot.org/citations/27373307 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27373307 | http://www.w3.org/2000/01/rdf-schema#comment | "The EphA4 receptor tyrosine kinase is involved in numerous cell-signalling activities during embryonic development. EphA4 has the ability to bind to both types of ephrin ligands, the ephrinAs and ephrinBs. The C57BL/6J-Epha4rb-2J/GrsrJ strain, denoted Epha4(rb-2J/rb-2J), is a spontaneous mouse mutant that arose at The Jackson Laboratory. These mutants exhibited a synchronous hind limb locomotion defect or "hopping gait" phenotype, which is also characteristic of EphA4 null mice. Genetic complementation experiments suggested that Epha4(rb-2J) corresponds to an allele of EphA4, but details of the genomic defect in this mouse mutant are currently unavailable. We found a single base-pair deletion in exon 9 resulting in a frame shift mutation that subsequently resulted in a premature stop codon. Analysis of the predicted structure of the truncated protein suggests that both the kinase and sterile α motif (SAM) domains are absent. Definitive determination of genotype is needed for experimental studies of mice carrying the Epha4(rb-2J) allele, and we have also developed a method to ease detection of the mutation through RFLP. Eph-ephrin family members are reportedly expressed as numerous isoforms. Hence, delineation of the specific mutation in EphA4 in this strain is important for further functional studies, such as protein-protein interactions, immunostaining and gene compensatory studies, investigating the mechanism underlying the effects of altered function of Eph family of receptor tyrosine kinases on phenotype."xsd:string |
| http://purl.uniprot.org/citations/27373307 | http://purl.org/dc/terms/identifier | "doi:10.1139/gen-2015-0142"xsd:string |
| http://purl.uniprot.org/citations/27373307 | http://purl.uniprot.org/core/author | "Williams S.M."xsd:string |
| http://purl.uniprot.org/citations/27373307 | http://purl.uniprot.org/core/author | "Greene N.D."xsd:string |
| http://purl.uniprot.org/citations/27373307 | http://purl.uniprot.org/core/author | "Abdullah A."xsd:string |
| http://purl.uniprot.org/citations/27373307 | http://purl.uniprot.org/core/author | "Ahmad-Annuar A."xsd:string |
| http://purl.uniprot.org/citations/27373307 | http://purl.uniprot.org/core/author | "Abdul-Aziz N.M."xsd:string |
| http://purl.uniprot.org/citations/27373307 | http://purl.uniprot.org/core/author | "Ling K.H."xsd:string |
| http://purl.uniprot.org/citations/27373307 | http://purl.uniprot.org/core/author | "Mohd-Zin S.W."xsd:string |
| http://purl.uniprot.org/citations/27373307 | http://purl.uniprot.org/core/author | "Cheah P.S."xsd:string |
| http://purl.uniprot.org/citations/27373307 | http://purl.uniprot.org/core/author | "Abdullah N.L."xsd:string |
| http://purl.uniprot.org/citations/27373307 | http://purl.uniprot.org/core/author | "Marwan A.I."xsd:string |
| http://purl.uniprot.org/citations/27373307 | http://purl.uniprot.org/core/author | "York K.T."xsd:string |
| http://purl.uniprot.org/citations/27373307 | http://purl.uniprot.org/core/author | "Yusof H."xsd:string |
| http://purl.uniprot.org/citations/27373307 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27373307 | http://purl.uniprot.org/core/name | "Genome"xsd:string |
| http://purl.uniprot.org/citations/27373307 | http://purl.uniprot.org/core/pages | "439-448"xsd:string |
| http://purl.uniprot.org/citations/27373307 | http://purl.uniprot.org/core/title | "Identification of the genomic mutation in Epha4(rb-2J/rb-2J) mice."xsd:string |
| http://purl.uniprot.org/citations/27373307 | http://purl.uniprot.org/core/volume | "59"xsd:string |
| http://purl.uniprot.org/citations/27373307 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27373307 |
| http://purl.uniprot.org/citations/27373307 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27373307 |
| http://purl.uniprot.org/uniprot/#_A0A087WQW6-mappedCitation-27373307 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27373307 |
| http://purl.uniprot.org/uniprot/#_A0A087WQZ6-mappedCitation-27373307 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27373307 |
| http://purl.uniprot.org/uniprot/#_A0A087WRH4-mappedCitation-27373307 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27373307 |