| http://purl.uniprot.org/citations/27373369 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27373369 | http://www.w3.org/2000/01/rdf-schema#comment | "A central question in Alzheimer's Disease (AD) is whether the neuritic plaque is necessary and sufficient for the development of tau pathology. Hyperphosphorylation of tau is found within dystrophic neurites surrounding β-amyloid deposits in AD mouse models but the pathological conversion of tau is absent. Likewise, expression of a human tau repeat domain in mice is insufficient to drive the pathological conversion of tau. Here we developed an Aβ-amyloidosis mouse model that expresses the human tau repeat domain and show that in these mice, the neuritic plaque facilitates the pathological conversion of wild-type tau. We show that this tau fragment seeds the neuritic plaque-dependent pathological conversion of wild-type tau that spreads from the cortex and hippocampus to the brain stem. These results establish that in addition to the neuritic plaque, a second determinant is required to drive the conversion of wild-type tau."xsd:string |
| http://purl.uniprot.org/citations/27373369 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms12082"xsd:string |
| http://purl.uniprot.org/citations/27373369 | http://purl.uniprot.org/core/author | "Li T."xsd:string |
| http://purl.uniprot.org/citations/27373369 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/27373369 | http://purl.uniprot.org/core/author | "Wong P.C."xsd:string |
| http://purl.uniprot.org/citations/27373369 | http://purl.uniprot.org/core/author | "Lau A."xsd:string |
| http://purl.uniprot.org/citations/27373369 | http://purl.uniprot.org/core/author | "Braunstein K.E."xsd:string |
| http://purl.uniprot.org/citations/27373369 | http://purl.uniprot.org/core/author | "Deeble C."xsd:string |
| http://purl.uniprot.org/citations/27373369 | http://purl.uniprot.org/core/author | "Sibener L."xsd:string |
| http://purl.uniprot.org/citations/27373369 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27373369 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/27373369 | http://purl.uniprot.org/core/pages | "12082"xsd:string |
| http://purl.uniprot.org/citations/27373369 | http://purl.uniprot.org/core/title | "The neuritic plaque facilitates pathological conversion of tau in an Alzheimer's disease mouse model."xsd:string |
| http://purl.uniprot.org/citations/27373369 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/27373369 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27373369 |
| http://purl.uniprot.org/citations/27373369 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27373369 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MQC7-mappedCitation-27373369 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27373369 |
| http://purl.uniprot.org/uniprot/#_A2A5Y6-mappedCitation-27373369 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27373369 |
| http://purl.uniprot.org/uniprot/#_B1AQW2-mappedCitation-27373369 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27373369 |
| http://purl.uniprot.org/uniprot/#_B1AQW4-mappedCitation-27373369 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27373369 |
| http://purl.uniprot.org/uniprot/#_B1AQW5-mappedCitation-27373369 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27373369 |
| http://purl.uniprot.org/uniprot/#_B1AQW6-mappedCitation-27373369 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27373369 |
| http://purl.uniprot.org/uniprot/#_P10637-mappedCitation-27373369 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27373369 |
| http://purl.uniprot.org/uniprot/#_Q3UH19-mappedCitation-27373369 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27373369 |