| http://purl.uniprot.org/citations/27373979 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27373979 | http://www.w3.org/2000/01/rdf-schema#comment | "Curcumin can be used to prevent and treat cancer. However, its exact underlying molecular mechanisms remain poorly understood. Cathepsin L, a lysosomal cysteine protease, is overexpressed in several cancer types. This study aimed to determine the role of cathepsin L in curcumin-mediated inhibition of growth, migration, and invasion of glioma cells. Results revealed that the activity of cathepsin L was enhanced in curcumin-treated glioma cells. Cathepsin L knockdown induced by RNA interference significantly promoted curcumin-induced cytotoxicity, apoptosis, and cell cycle arrest. The knockdown also inhibited the migration and invasion of glioma cells. Our results suggested that the inhibition of cathepsin L can enhance the sensitivity of glioma cells to curcumin. Therefore, cathepsin L may be a new target to enhance the efficacy of curcumin against cancers."xsd:string |
| http://purl.uniprot.org/citations/27373979 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.brainres.2016.06.046"xsd:string |
| http://purl.uniprot.org/citations/27373979 | http://purl.uniprot.org/core/author | "Han M."xsd:string |
| http://purl.uniprot.org/citations/27373979 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/27373979 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/27373979 | http://purl.uniprot.org/core/author | "Zhao Y."xsd:string |
| http://purl.uniprot.org/citations/27373979 | http://purl.uniprot.org/core/author | "Xiong Y."xsd:string |
| http://purl.uniprot.org/citations/27373979 | http://purl.uniprot.org/core/author | "Liang Z."xsd:string |
| http://purl.uniprot.org/citations/27373979 | http://purl.uniprot.org/core/author | "Tan C."xsd:string |
| http://purl.uniprot.org/citations/27373979 | http://purl.uniprot.org/core/author | "Fei Y."xsd:string |
| http://purl.uniprot.org/citations/27373979 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27373979 | http://purl.uniprot.org/core/name | "Brain Res"xsd:string |
| http://purl.uniprot.org/citations/27373979 | http://purl.uniprot.org/core/pages | "580-588"xsd:string |
| http://purl.uniprot.org/citations/27373979 | http://purl.uniprot.org/core/title | "Cathepsin L knockdown enhances curcumin-mediated inhibition of growth, migration, and invasion of glioma cells."xsd:string |
| http://purl.uniprot.org/citations/27373979 | http://purl.uniprot.org/core/volume | "1646"xsd:string |
| http://purl.uniprot.org/citations/27373979 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27373979 |
| http://purl.uniprot.org/citations/27373979 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27373979 |
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