| http://purl.uniprot.org/citations/27374788 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27374788 | http://www.w3.org/2000/01/rdf-schema#comment | "Adipose tissue (AT) has previously been identified as an extra-medullary reservoir for normal hematopoietic stem cells (HSCs) and may promote tumor development. Here, we show that a subpopulation of leukemic stem cells (LSCs) can utilize gonadal adipose tissue (GAT) as a niche to support their metabolism and evade chemotherapy. In a mouse model of blast crisis chronic myeloid leukemia (CML), adipose-resident LSCs exhibit a pro-inflammatory phenotype and induce lipolysis in GAT. GAT lipolysis fuels fatty acid oxidation in LSCs, especially within a subpopulation expressing the fatty acid transporter CD36. CD36(+) LSCs have unique metabolic properties, are strikingly enriched in AT, and are protected from chemotherapy by the GAT microenvironment. CD36 also marks a fraction of human blast crisis CML and acute myeloid leukemia (AML) cells with similar biological properties. These findings suggest striking interplay between leukemic cells and AT to create a unique microenvironment that supports the metabolic demands and survival of a distinct LSC subpopulation."xsd:string |
| http://purl.uniprot.org/citations/27374788 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.stem.2016.06.001"xsd:string |
| http://purl.uniprot.org/citations/27374788 | http://purl.uniprot.org/core/author | "Khan N."xsd:string |
| http://purl.uniprot.org/citations/27374788 | http://purl.uniprot.org/core/author | "Ye H."xsd:string |
| http://purl.uniprot.org/citations/27374788 | http://purl.uniprot.org/core/author | "Ashton J.M."xsd:string |
| http://purl.uniprot.org/citations/27374788 | http://purl.uniprot.org/core/author | "Park C.Y."xsd:string |
| http://purl.uniprot.org/citations/27374788 | http://purl.uniprot.org/core/author | "Jordan C.T."xsd:string |
| http://purl.uniprot.org/citations/27374788 | http://purl.uniprot.org/core/author | "Stevens B."xsd:string |
| http://purl.uniprot.org/citations/27374788 | http://purl.uniprot.org/core/author | "Sullivan T."xsd:string |
| http://purl.uniprot.org/citations/27374788 | http://purl.uniprot.org/core/author | "Klemm D.J."xsd:string |
| http://purl.uniprot.org/citations/27374788 | http://purl.uniprot.org/core/author | "Pei S."xsd:string |
| http://purl.uniprot.org/citations/27374788 | http://purl.uniprot.org/core/author | "Minhajuddin M."xsd:string |
| http://purl.uniprot.org/citations/27374788 | http://purl.uniprot.org/core/author | "Gasparetto M."xsd:string |
| http://purl.uniprot.org/citations/27374788 | http://purl.uniprot.org/core/author | "Woolthuis C.M."xsd:string |
| http://purl.uniprot.org/citations/27374788 | http://purl.uniprot.org/core/author | "Balys M."xsd:string |
| http://purl.uniprot.org/citations/27374788 | http://purl.uniprot.org/core/author | "Adane B."xsd:string |
| http://purl.uniprot.org/citations/27374788 | http://purl.uniprot.org/core/author | "Stranahan A.W."xsd:string |
| http://purl.uniprot.org/citations/27374788 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27374788 | http://purl.uniprot.org/core/name | "Cell Stem Cell"xsd:string |
| http://purl.uniprot.org/citations/27374788 | http://purl.uniprot.org/core/pages | "23-37"xsd:string |
| http://purl.uniprot.org/citations/27374788 | http://purl.uniprot.org/core/title | "Leukemic Stem Cells Evade Chemotherapy by Metabolic Adaptation to an Adipose Tissue Niche."xsd:string |
| http://purl.uniprot.org/citations/27374788 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/27374788 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27374788 |
| http://purl.uniprot.org/citations/27374788 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27374788 |