| http://purl.uniprot.org/citations/27378146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27378146 | http://www.w3.org/2000/01/rdf-schema#comment | "Chromosome 16p13.11 microduplication is a risk factor associated with various neurodevelopmental disorders such as attention-deficit/hyperactivity disorder, intellectual disabilities, developmental delay and autistic spectrum disorder. The underlying molecular mechanism of this genetic variation remained unknown, but its core genetic locus-conserved across mice and humans-contains seven genes. Here, we generated bacterial artificial chromosome-transgenic mice carrying a human 16p13.11 locus, and these mice showed the behavioral hyperactivity phenotype. We identified miR-484 as the responsible gene using a combination of expression and functional analyses. Mature miR-484 was expressed during active cortical neurogenesis, and overexpression of miR-484 decreased proliferation and increased neural progenitor differentiation in vivo. Luciferase screening identified the 3'-untranslated region of protocadherin-19 (Pcdh19) as a target of miR-484. The effect of miR-484 on neurogenesis was rescued by ectopic PCDH19 expression. These results demonstrate that miR-484 promotes neurogenesis by inhibiting PCDH19. Dysregulation of neurogenesis by imbalanced miR-484/PCDH19 expression contributes to the pathogenesis of 16p13.11 microduplication syndrome."xsd:string |
| http://purl.uniprot.org/citations/27378146 | http://purl.org/dc/terms/identifier | "doi:10.1038/mp.2016.106"xsd:string |
| http://purl.uniprot.org/citations/27378146 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/27378146 | http://purl.uniprot.org/core/author | "Yamashita T."xsd:string |
| http://purl.uniprot.org/citations/27378146 | http://purl.uniprot.org/core/author | "Fujiki R."xsd:string |
| http://purl.uniprot.org/citations/27378146 | http://purl.uniprot.org/core/author | "Fujihara Y."xsd:string |
| http://purl.uniprot.org/citations/27378146 | http://purl.uniprot.org/core/author | "Fujitani M."xsd:string |
| http://purl.uniprot.org/citations/27378146 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/27378146 | http://purl.uniprot.org/core/name | "Mol Psychiatry"xsd:string |
| http://purl.uniprot.org/citations/27378146 | http://purl.uniprot.org/core/pages | "364-374"xsd:string |
| http://purl.uniprot.org/citations/27378146 | http://purl.uniprot.org/core/title | "A chromosome 16p13.11 microduplication causes hyperactivity through dysregulation of miR-484/protocadherin-19 signaling."xsd:string |
| http://purl.uniprot.org/citations/27378146 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/27378146 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27378146 |
| http://purl.uniprot.org/citations/27378146 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27378146 |
| http://purl.uniprot.org/uniprot/#_D3YYJ6-mappedCitation-27378146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27378146 |
| http://purl.uniprot.org/uniprot/#_A5D6P3-mappedCitation-27378146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27378146 |
| http://purl.uniprot.org/uniprot/#_A0A1Y7VLJ9-mappedCitation-27378146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27378146 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VH96-mappedCitation-27378146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27378146 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VHF9-mappedCitation-27378146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27378146 |
| http://purl.uniprot.org/uniprot/#_A0A338P6K2-mappedCitation-27378146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27378146 |
| http://purl.uniprot.org/uniprot/#_A2AGW4-mappedCitation-27378146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27378146 |
| http://purl.uniprot.org/uniprot/#_E9Q1I5-mappedCitation-27378146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27378146 |
| http://purl.uniprot.org/uniprot/#_E9QPE7-mappedCitation-27378146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27378146 |
| http://purl.uniprot.org/uniprot/#_D3Z407-mappedCitation-27378146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27378146 |