| http://purl.uniprot.org/citations/27378793 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27378793 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundAntidepressant-worsening suicidal ideation is a rare but serious phenomenon. This study aimed to test for association between antidepressant-worsening suicidal ideation and polymorphisms of BDNF/NTRK2 neurotrophin pathway genes, known to be involved in depression and suicide.MethodsThis was a case-control study comparing patients with antidepressant-worsening suicidal ideation to patients without. Patients were collected from the GENESE cohort (3771 depressed tianeptine-treated outpatients). Antidepressant-worsening suicidal ideation was defined by an increase of at least 2 points on the Montgomery-Åsberg Depression Rating Scale-item10 during treatment. Controls were matched for age, sex, and baseline Montgomery-Åsberg Depression Rating Scale-item10 score. Thirteen single nucleotide polymorphisms covering 5 BDNF/NTRK2 pathway genes were genotyped.ResultsA total 78 cases and 312 controls were included. Two NTRK2 single nucleotide polymorphisms were associated to antidepressant-worsening suicidal ideation: rs1439050 (P=.01) and rs1867283 (P=.04). Association with rs1439050 remained significant after adjustment for potentially confounding factors, including previous suicide attempts (P<.01).ConclusionsThis naturalistic prospective study is consistent with previous studies on highlighting the potential role of the neurotrophin pathway, and especially of NTRK2, in antidepressant-worsening suicidal ideation."xsd:string |
| http://purl.uniprot.org/citations/27378793 | http://purl.org/dc/terms/identifier | "doi:10.1093/ijnp/pyw059"xsd:string |
| http://purl.uniprot.org/citations/27378793 | http://purl.uniprot.org/core/author | "Gorwood P."xsd:string |
| http://purl.uniprot.org/citations/27378793 | http://purl.uniprot.org/core/author | "Courtet P."xsd:string |
| http://purl.uniprot.org/citations/27378793 | http://purl.uniprot.org/core/author | "Ramoz N."xsd:string |
| http://purl.uniprot.org/citations/27378793 | http://purl.uniprot.org/core/author | "Kelsoe J.R."xsd:string |
| http://purl.uniprot.org/citations/27378793 | http://purl.uniprot.org/core/author | "Shekhtman T."xsd:string |
| http://purl.uniprot.org/citations/27378793 | http://purl.uniprot.org/core/author | "Voegeli G."xsd:string |
| http://purl.uniprot.org/citations/27378793 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27378793 | http://purl.uniprot.org/core/name | "Int J Neuropsychopharmacol"xsd:string |
| http://purl.uniprot.org/citations/27378793 | http://purl.uniprot.org/core/pages | "pyw059"xsd:string |
| http://purl.uniprot.org/citations/27378793 | http://purl.uniprot.org/core/title | "Neurotrophin Genes and Antidepressant-Worsening Suicidal Ideation: A Prospective Case-Control Study."xsd:string |
| http://purl.uniprot.org/citations/27378793 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/27378793 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27378793 |
| http://purl.uniprot.org/citations/27378793 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27378793 |
| http://purl.uniprot.org/uniprot/#_A0A8I5KR47-mappedCitation-27378793 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27378793 |
| http://purl.uniprot.org/uniprot/#_Q16620-mappedCitation-27378793 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27378793 |
| http://purl.uniprot.org/uniprot/#_Q5VWE5-mappedCitation-27378793 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27378793 |
| http://purl.uniprot.org/uniprot/#_Q548C2-mappedCitation-27378793 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27378793 |
| http://purl.uniprot.org/uniprot/#_Q8WXJ4-mappedCitation-27378793 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27378793 |
| http://purl.uniprot.org/uniprot/#_Q8WXJ8-mappedCitation-27378793 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27378793 |
| http://purl.uniprot.org/uniprot/#_S5MD53-mappedCitation-27378793 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27378793 |
| http://purl.uniprot.org/uniprot/Q16620 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27378793 |
| http://purl.uniprot.org/uniprot/Q548C2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27378793 |