| http://purl.uniprot.org/citations/27381865 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27381865 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27381865 | http://www.w3.org/2000/01/rdf-schema#comment | "Crystal (Cry) proteins from Bacillus thuringiensis (Bt) are globally used in agriculture as proteinaceous insecticides. Numerous crystal structures have been determined, and most exhibit conserved three-dimensional architectures. Recently, we have identified a novel nematicidal mechanism by which Cry6Aa triggers cell death through a necrosis-signaling pathway via an interaction with the host protease ASP-1. However, we found little sequence conservation of Cry6Aa in our functional study. Here, we report the 1.90 angstrom (Å) resolution structure of the proteolytic form of Cry6Aa (1-396), determined by X-ray crystallography. The structure of Cry6Aa is highly similar to those of the pathogenic toxin family of ClyA-type α-pore-forming toxins (α-PFTs), which are characterized by a bipartite structure comprising a head domain and a tail domain, thus suggesting that Cry6Aa exhibits a previously undescribed nematicidal mode of action. This structure also provides a framework for the functional study of other nematicidal toxins."xsd:string |
| http://purl.uniprot.org/citations/27381865 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2016.07.002"xsd:string |
| http://purl.uniprot.org/citations/27381865 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2016.07.002"xsd:string |
| http://purl.uniprot.org/citations/27381865 | http://purl.uniprot.org/core/author | "Huang J."xsd:string |
| http://purl.uniprot.org/citations/27381865 | http://purl.uniprot.org/core/author | "Huang J."xsd:string |
| http://purl.uniprot.org/citations/27381865 | http://purl.uniprot.org/core/author | "Guan Z."xsd:string |
| http://purl.uniprot.org/citations/27381865 | http://purl.uniprot.org/core/author | "Guan Z."xsd:string |
| http://purl.uniprot.org/citations/27381865 | http://purl.uniprot.org/core/author | "Sun M."xsd:string |
| http://purl.uniprot.org/citations/27381865 | http://purl.uniprot.org/core/author | "Sun M."xsd:string |
| http://purl.uniprot.org/citations/27381865 | http://purl.uniprot.org/core/author | "Wan L."xsd:string |
| http://purl.uniprot.org/citations/27381865 | http://purl.uniprot.org/core/author | "Wan L."xsd:string |
| http://purl.uniprot.org/citations/27381865 | http://purl.uniprot.org/core/author | "Zou T."xsd:string |
| http://purl.uniprot.org/citations/27381865 | http://purl.uniprot.org/core/author | "Zou T."xsd:string |
| http://purl.uniprot.org/citations/27381865 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27381865 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27381865 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/27381865 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/27381865 | http://purl.uniprot.org/core/pages | "307-313"xsd:string |
| http://purl.uniprot.org/citations/27381865 | http://purl.uniprot.org/core/pages | "307-313"xsd:string |
| http://purl.uniprot.org/citations/27381865 | http://purl.uniprot.org/core/title | "Crystal structure of Cry6Aa: A novel nematicidal ClyA-type alpha-pore-forming toxin from Bacillus thuringiensis."xsd:string |
| http://purl.uniprot.org/citations/27381865 | http://purl.uniprot.org/core/title | "Crystal structure of Cry6Aa: A novel nematicidal ClyA-type alpha-pore-forming toxin from Bacillus thuringiensis."xsd:string |
| http://purl.uniprot.org/citations/27381865 | http://purl.uniprot.org/core/volume | "478"xsd:string |
| http://purl.uniprot.org/citations/27381865 | http://purl.uniprot.org/core/volume | "478"xsd:string |