| http://purl.uniprot.org/citations/27396830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27396830 | http://www.w3.org/2000/01/rdf-schema#comment | "Cullin-RING E3 ligases (CRLs) are elongated and bowed protein complexes that transfer ubiquitin over 60 Å to proteins targeted for proteasome degradation. One such CRL contains the ankyrin repeat and SOCS box protein 9 (ASB9), which binds to and partially inhibits creatine kinase (CK). While current models for the ASB9-CK complex contain some known interface residues, the overall structure and precise interface of the ASB9-CK complex remains unknown. Through an integrative modeling approach, we report a third-generation model that reveals precisely the interface interactions and also fits the shape of the ASB9-CK complex as determined by small-angle X-ray scattering. We constructed an atomic model for the entire CK-targeting CRL to uncover dominant modes of motion that could permit ubiquitin transfer. Remarkably, only the correctly docked CK-containing E3 ligase and not incorrectly docked structures permitted close approach of ubiquitin to the CK substrate."xsd:string |
| http://purl.uniprot.org/citations/27396830 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2016.05.016"xsd:string |
| http://purl.uniprot.org/citations/27396830 | http://purl.uniprot.org/core/author | "Komives E.A."xsd:string |
| http://purl.uniprot.org/citations/27396830 | http://purl.uniprot.org/core/author | "Amaro R.E."xsd:string |
| http://purl.uniprot.org/citations/27396830 | http://purl.uniprot.org/core/author | "Reyes J."xsd:string |
| http://purl.uniprot.org/citations/27396830 | http://purl.uniprot.org/core/author | "Schiffer J.M."xsd:string |
| http://purl.uniprot.org/citations/27396830 | http://purl.uniprot.org/core/author | "Parnell J."xsd:string |
| http://purl.uniprot.org/citations/27396830 | http://purl.uniprot.org/core/author | "Malmstrom R.D."xsd:string |
| http://purl.uniprot.org/citations/27396830 | http://purl.uniprot.org/core/author | "Ramirez-Sarmiento C."xsd:string |
| http://purl.uniprot.org/citations/27396830 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27396830 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/27396830 | http://purl.uniprot.org/core/pages | "1248-1256"xsd:string |
| http://purl.uniprot.org/citations/27396830 | http://purl.uniprot.org/core/title | "Model of the Ankyrin and SOCS Box Protein, ASB9, E3 Ligase Reveals a Mechanism for Dynamic Ubiquitin Transfer."xsd:string |
| http://purl.uniprot.org/citations/27396830 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/27396830 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27396830 |
| http://purl.uniprot.org/citations/27396830 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27396830 |
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