| http://purl.uniprot.org/citations/27397685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27397685 | http://www.w3.org/2000/01/rdf-schema#comment | "Replisome assembly at eukaryotic replication forks connects the DNA helicase to DNA polymerases and many other factors. The helicase binds the leading-strand polymerase directly, but is connected to the Pol α lagging-strand polymerase by the trimeric adaptor Ctf4. Here, we identify new Ctf4 partners in addition to Pol α and helicase, all of which contain a "Ctf4-interacting-peptide" or CIP-box. Crystallographic analysis classifies CIP-boxes into two related groups that target different sites on Ctf4. Mutations in the CIP-box motifs of the Dna2 nuclease or the rDNA-associated protein Tof2 do not perturb DNA synthesis genome-wide, but instead lead to a dramatic shortening of chromosome 12 that contains the large array of rDNA repeats. Our data reveal unexpected complexity of Ctf4 function, as a hub that connects multiple accessory factors to the replisome. Most strikingly, Ctf4-dependent recruitment of CIP-box proteins couples other processes to DNA synthesis, including rDNA copy-number regulation."xsd:string |
| http://purl.uniprot.org/citations/27397685 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2016.06.009"xsd:string |
| http://purl.uniprot.org/citations/27397685 | http://purl.uniprot.org/core/author | "Kilkenny M.L."xsd:string |
| http://purl.uniprot.org/citations/27397685 | http://purl.uniprot.org/core/author | "Pellegrini L."xsd:string |
| http://purl.uniprot.org/citations/27397685 | http://purl.uniprot.org/core/author | "Labib K."xsd:string |
| http://purl.uniprot.org/citations/27397685 | http://purl.uniprot.org/core/author | "Wightman M."xsd:string |
| http://purl.uniprot.org/citations/27397685 | http://purl.uniprot.org/core/author | "Villa F."xsd:string |
| http://purl.uniprot.org/citations/27397685 | http://purl.uniprot.org/core/author | "Matak-Vinkovic D."xsd:string |
| http://purl.uniprot.org/citations/27397685 | http://purl.uniprot.org/core/author | "Simon A.C."xsd:string |
| http://purl.uniprot.org/citations/27397685 | http://purl.uniprot.org/core/author | "Ortiz Bazan M.A."xsd:string |
| http://purl.uniprot.org/citations/27397685 | http://purl.uniprot.org/core/author | "Wirthensohn D."xsd:string |
| http://purl.uniprot.org/citations/27397685 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27397685 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/27397685 | http://purl.uniprot.org/core/pages | "385-396"xsd:string |
| http://purl.uniprot.org/citations/27397685 | http://purl.uniprot.org/core/title | "Ctf4 Is a Hub in the Eukaryotic Replisome that Links Multiple CIP-Box Proteins to the CMG Helicase."xsd:string |
| http://purl.uniprot.org/citations/27397685 | http://purl.uniprot.org/core/volume | "63"xsd:string |
| http://purl.uniprot.org/citations/27397685 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27397685 |
| http://purl.uniprot.org/citations/27397685 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27397685 |
| http://purl.uniprot.org/uniprot/#_A0A8H4BWA2-mappedCitation-27397685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27397685 |
| http://purl.uniprot.org/uniprot/#_A0A8H4BY16-mappedCitation-27397685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27397685 |
| http://purl.uniprot.org/uniprot/#_Q02208-mappedCitation-27397685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27397685 |
| http://purl.uniprot.org/uniprot/#_P38859-mappedCitation-27397685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27397685 |
| http://purl.uniprot.org/uniprot/#_Q01454-mappedCitation-27397685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27397685 |
| http://purl.uniprot.org/uniprot/Q01454 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27397685 |