| http://purl.uniprot.org/citations/27398409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27398409 | http://www.w3.org/2000/01/rdf-schema#comment | "Airway and/or lung remodeling, involving exaggerated extracellular matrix (ECM) protein deposition, is a critical feature common to pulmonary diseases including chronic obstructive pulmonary disease (COPD), asthma, and idiopathic pulmonary fibrosis (IPF). Fibulin-1 (Fbln1), an important ECM protein involved in matrix organization, may be involved in the pathogenesis of these diseases. We found that Fbln1 was increased in COPD patients and in cigarette smoke-induced (CS-induced) experimental COPD in mice. Genetic or therapeutic inhibition of Fbln1c protected against CS-induced airway fibrosis and emphysema-like alveolar enlargement. In experimental COPD, this occurred through disrupted collagen organization and interactions with fibronectin, periostin, and tenascin-c. Genetic inhibition of Fbln1c also reduced levels of pulmonary inflammatory cells and proinflammatory cytokines/chemokines (TNF-α, IL-33, and CXCL1) in experimental COPD. Fbln1c-/- mice also had reduced airway remodeling in experimental chronic asthma and pulmonary fibrosis. Our data show that Fbln1c may be a therapeutic target in chronic respiratory diseases."xsd:string |
| http://purl.uniprot.org/citations/27398409 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci.insight.86380"xsd:string |
| http://purl.uniprot.org/citations/27398409 | http://purl.uniprot.org/core/author | "Liu G."xsd:string |
| http://purl.uniprot.org/citations/27398409 | http://purl.uniprot.org/core/author | "Oliver B.G."xsd:string |
| http://purl.uniprot.org/citations/27398409 | http://purl.uniprot.org/core/author | "Jarnicki A.G."xsd:string |
| http://purl.uniprot.org/citations/27398409 | http://purl.uniprot.org/core/author | "Hansbro P.M."xsd:string |
| http://purl.uniprot.org/citations/27398409 | http://purl.uniprot.org/core/author | "Argraves W.S."xsd:string |
| http://purl.uniprot.org/citations/27398409 | http://purl.uniprot.org/core/author | "Fricker M."xsd:string |
| http://purl.uniprot.org/citations/27398409 | http://purl.uniprot.org/core/author | "Kim R.Y."xsd:string |
| http://purl.uniprot.org/citations/27398409 | http://purl.uniprot.org/core/author | "Nair P.M."xsd:string |
| http://purl.uniprot.org/citations/27398409 | http://purl.uniprot.org/core/author | "Horvat J.C."xsd:string |
| http://purl.uniprot.org/citations/27398409 | http://purl.uniprot.org/core/author | "Burgess J.K."xsd:string |
| http://purl.uniprot.org/citations/27398409 | http://purl.uniprot.org/core/author | "Walker M.M."xsd:string |
| http://purl.uniprot.org/citations/27398409 | http://purl.uniprot.org/core/author | "Gellatly S.L."xsd:string |
| http://purl.uniprot.org/citations/27398409 | http://purl.uniprot.org/core/author | "Inman M.D."xsd:string |
| http://purl.uniprot.org/citations/27398409 | http://purl.uniprot.org/core/author | "Knight D.A."xsd:string |
| http://purl.uniprot.org/citations/27398409 | http://purl.uniprot.org/core/author | "Wark P.A."xsd:string |
| http://purl.uniprot.org/citations/27398409 | http://purl.uniprot.org/core/author | "Hsu A.C."xsd:string |
| http://purl.uniprot.org/citations/27398409 | http://purl.uniprot.org/core/author | "Cooley M.A."xsd:string |
| http://purl.uniprot.org/citations/27398409 | http://purl.uniprot.org/core/author | "Tjin G."xsd:string |
| http://purl.uniprot.org/citations/27398409 | http://purl.uniprot.org/core/author | "Haw T.J."xsd:string |
| http://purl.uniprot.org/citations/27398409 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27398409 | http://purl.uniprot.org/core/name | "JCI Insight"xsd:string |
| http://purl.uniprot.org/citations/27398409 | http://purl.uniprot.org/core/pages | "e86380"xsd:string |