| http://purl.uniprot.org/citations/27398911 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27398911 | http://www.w3.org/2000/01/rdf-schema#comment | "Transforming growth factor-β (TGF-β) induces the expression of Disabled-2 (Dab2), an endocytic adaptor and tumour suppressor, concomitant with the induction of an epithelial-mesenchymal transition (EMT) in mammary epithelial cells. Here we show that following TGF-β-mediated EMT, sustained TGF-β treatment leads to proteolytic degradation of Dab2 by cathepsin B (CTSB), loss of the mesenchymal phenotype and induction of autophagy. CTSB inhibition or expression of a CTSB-resistant Dab2 mutant maintains Dab2 expression and shifts long-term TGF-β-treated cells from autophagy to apoptosis. We further show that Dab2 interacts with Beclin-1 to promote casein-kinase-2-mediated phosphorylation of Beclin-1, preventing Beclin-1-Vps34 interaction and subsequent autophagosome assembly. Thus, CTSB-mediated degradation of Dab2 allows Beclin-1-Vps34 induction of autophagy, whereas sustained Dab2 expression prevents autophagy and promotes apoptosis by stabilizing the pro-apoptotic Bim protein. In vivo studies suggest that Dab2-mediated regulation of autophagy modulates chemotherapeutic resistance and tumour metastasis."xsd:string |
| http://purl.uniprot.org/citations/27398911 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb3388"xsd:string |
| http://purl.uniprot.org/citations/27398911 | http://purl.uniprot.org/core/author | "Jiang Y."xsd:string |
| http://purl.uniprot.org/citations/27398911 | http://purl.uniprot.org/core/author | "Howe P.H."xsd:string |
| http://purl.uniprot.org/citations/27398911 | http://purl.uniprot.org/core/author | "Natarajan S."xsd:string |
| http://purl.uniprot.org/citations/27398911 | http://purl.uniprot.org/core/author | "Woosley A.N."xsd:string |
| http://purl.uniprot.org/citations/27398911 | http://purl.uniprot.org/core/author | "Sivalingam N."xsd:string |
| http://purl.uniprot.org/citations/27398911 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27398911 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/27398911 | http://purl.uniprot.org/core/pages | "851-863"xsd:string |
| http://purl.uniprot.org/citations/27398911 | http://purl.uniprot.org/core/title | "Cathepsin-B-mediated cleavage of Disabled-2 regulates TGF-beta-induced autophagy."xsd:string |
| http://purl.uniprot.org/citations/27398911 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/27398911 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27398911 |
| http://purl.uniprot.org/citations/27398911 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27398911 |
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| http://purl.uniprot.org/uniprot/#_A0A0R4J104-mappedCitation-27398911 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27398911 |
| http://purl.uniprot.org/uniprot/#_A8K2H4-mappedCitation-27398911 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27398911 |
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| http://purl.uniprot.org/uniprot/#_B4DMY4-mappedCitation-27398911 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27398911 |
| http://purl.uniprot.org/uniprot/#_B4DNN1-mappedCitation-27398911 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27398911 |
| http://purl.uniprot.org/uniprot/#_E9QL31-mappedCitation-27398911 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27398911 |
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| http://purl.uniprot.org/uniprot/#_B4DL49-mappedCitation-27398911 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27398911 |