| http://purl.uniprot.org/citations/27400149 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27400149 | http://www.w3.org/2000/01/rdf-schema#comment | "Adhesion and migration of T cells are controlled by chemokines and by adhesion molecules, especially integrins, and have critical roles in the normal physiological function of T lymphocytes. Using an RNA-mediated interference screen, we identified the WNK1 kinase as a regulator of both integrin-mediated adhesion and T cell migration. We found that WNK1 is a negative regulator of integrin-mediated adhesion, whereas it acts as a positive regulator of migration via the kinases OXSR1 and STK39 and the ion co-transporter SLC12A2. WNK1-deficient T cells home less efficiently to lymphoid organs and migrate more slowly through them. Our results reveal that a pathway previously known only to regulate salt homeostasis in the kidney functions to balance T cell adhesion and migration."xsd:string |
| http://purl.uniprot.org/citations/27400149 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.3495"xsd:string |
| http://purl.uniprot.org/citations/27400149 | http://purl.uniprot.org/core/author | "Xie J."xsd:string |
| http://purl.uniprot.org/citations/27400149 | http://purl.uniprot.org/core/author | "Lyck R."xsd:string |
| http://purl.uniprot.org/citations/27400149 | http://purl.uniprot.org/core/author | "Tybulewicz V.L."xsd:string |
| http://purl.uniprot.org/citations/27400149 | http://purl.uniprot.org/core/author | "Kochl R."xsd:string |
| http://purl.uniprot.org/citations/27400149 | http://purl.uniprot.org/core/author | "Stein J.V."xsd:string |
| http://purl.uniprot.org/citations/27400149 | http://purl.uniprot.org/core/author | "Huang C.L."xsd:string |
| http://purl.uniprot.org/citations/27400149 | http://purl.uniprot.org/core/author | "Vanes L."xsd:string |
| http://purl.uniprot.org/citations/27400149 | http://purl.uniprot.org/core/author | "Fountain K."xsd:string |
| http://purl.uniprot.org/citations/27400149 | http://purl.uniprot.org/core/author | "Brazao T.F."xsd:string |
| http://purl.uniprot.org/citations/27400149 | http://purl.uniprot.org/core/author | "Thelen F."xsd:string |
| http://purl.uniprot.org/citations/27400149 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27400149 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
| http://purl.uniprot.org/citations/27400149 | http://purl.uniprot.org/core/pages | "1075-1083"xsd:string |
| http://purl.uniprot.org/citations/27400149 | http://purl.uniprot.org/core/title | "WNK1 kinase balances T cell adhesion versus migration in vivo."xsd:string |
| http://purl.uniprot.org/citations/27400149 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/27400149 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27400149 |
| http://purl.uniprot.org/citations/27400149 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27400149 |
| http://purl.uniprot.org/uniprot/P84444#attribution-B3502811C918CFA5DA8EA13E01BFC79B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/27400149 |
| http://purl.uniprot.org/uniprot/P06239#attribution-B3502811C918CFA5DA8EA13E01BFC79B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/27400149 |
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| http://purl.uniprot.org/uniprot/O95747#attribution-643D11B51ED790C3A97C6DF5641D4BE6 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/27400149 |
| http://purl.uniprot.org/uniprot/O95747#attribution-B3502811C918CFA5DA8EA13E01BFC79B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/27400149 |