| http://purl.uniprot.org/citations/27402827 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27402827 | http://www.w3.org/2000/01/rdf-schema#comment | "Wnt ligands play crucial roles in the development and regulation of synapse structure and function. Specifically, Wnt-5a acts as a secreted growth factor that regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the PSD-95 (postsynaptic density protein 95). Here, we focused on the early events occurring after the interaction between Wnt-5a and its Frizzled receptor at the neuronal cell surface. Additionally, we studied the role of heterotrimeric G proteins in Wnt-5a-dependent synaptic development. We report that FZD9 (Frizzled9), a Wnt receptor related to Williams syndrome, is localized in the postsynaptic region, where it interacts with Wnt-5a. Functionally, FZD9 is required for the Wnt-5a-mediated increase in dendritic spine density. FZD9 forms a precoupled complex with Gαo under basal conditions that dissociates after Wnt-5a stimulation. Accordingly, we found that G protein inhibition abrogates the Wnt-5a-dependent pathway in hippocampal neurons. In particular, the activation of Gαo appears to be a key factor controlling the Wnt-5a-induced dendritic spine density. In addition, we found that Gβγ is required for the Wnt-5a-mediated increase in cytosolic calcium levels and spinogenesis. Our findings reveal that FZD9 and heterotrimeric G proteins regulate Wnt-5a signaling and dendritic spines in cultured hippocampal neurons."xsd:string |
| http://purl.uniprot.org/citations/27402827 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m116.722132"xsd:string |
| http://purl.uniprot.org/citations/27402827 | http://purl.uniprot.org/core/author | "Inestrosa N.C."xsd:string |
| http://purl.uniprot.org/citations/27402827 | http://purl.uniprot.org/core/author | "Lorenzo A."xsd:string |
| http://purl.uniprot.org/citations/27402827 | http://purl.uniprot.org/core/author | "Henriquez J.P."xsd:string |
| http://purl.uniprot.org/citations/27402827 | http://purl.uniprot.org/core/author | "Ramos-Fernandez E."xsd:string |
| http://purl.uniprot.org/citations/27402827 | http://purl.uniprot.org/core/author | "Ramirez V.T."xsd:string |
| http://purl.uniprot.org/citations/27402827 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27402827 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/27402827 | http://purl.uniprot.org/core/pages | "19092-19107"xsd:string |
| http://purl.uniprot.org/citations/27402827 | http://purl.uniprot.org/core/title | "Wnt-5a/Frizzled9 Receptor Signaling through the Galphao-Gbetagamma Complex Regulates Dendritic Spine Formation."xsd:string |
| http://purl.uniprot.org/citations/27402827 | http://purl.uniprot.org/core/volume | "291"xsd:string |
| http://purl.uniprot.org/citations/27402827 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27402827 |
| http://purl.uniprot.org/citations/27402827 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27402827 |
| http://purl.uniprot.org/uniprot/Q8K4C8#attribution-4F25968E4FB80CDD6DE602E8A7751C3F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/27402827 |
| http://purl.uniprot.org/uniprot/P41221#attribution-4F25968E4FB80CDD6DE602E8A7751C3F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/27402827 |
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