| http://purl.uniprot.org/citations/2740350 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2740350 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2740350 | http://www.w3.org/2000/01/rdf-schema#comment | "Glial fibrillary acidic protein (GFAP) is an intermediate-filament (IF) protein that is highly specific for cells of astroglial lineage, although its tissue-specific role is speculative. Determination of the primary structure of this protein should be of importance for understanding the functional role it plays in astroglia. Therefore, we isolated a cDNA clone encoding this protein and determined its nucleotide sequence. The predicted amino acid sequence indicates that GFAP shares structural similarities--particularly in the central rod domain and to a lesser degree in the carboxyl-terminal domain--with other IF proteins found in nonepithelial cell types. Considerable sequence divergence in the amino-terminal region of GFAP suggests that the tissue-specific functions of this IF protein might be mediated through this region of the molecule. In contrast, conservation of structural characteristics and a moderate degree of sequence conservation in the carboxyl-terminal region suggest functional similarities. Blot hybridization analysis using the GFAP cDNA as a probe failed to detect GFAP mRNA in both normal and neoplastic human tissues in which IF proteins other than GFAP are known to be expressed."xsd:string |
| http://purl.uniprot.org/citations/2740350 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.86.13.5178"xsd:string |
| http://purl.uniprot.org/citations/2740350 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.86.13.5178"xsd:string |
| http://purl.uniprot.org/citations/2740350 | http://purl.uniprot.org/core/author | "Reeves S.A."xsd:string |
| http://purl.uniprot.org/citations/2740350 | http://purl.uniprot.org/core/author | "Reeves S.A."xsd:string |
| http://purl.uniprot.org/citations/2740350 | http://purl.uniprot.org/core/author | "Allison A."xsd:string |
| http://purl.uniprot.org/citations/2740350 | http://purl.uniprot.org/core/author | "Allison A."xsd:string |
| http://purl.uniprot.org/citations/2740350 | http://purl.uniprot.org/core/author | "Helman L.J."xsd:string |
| http://purl.uniprot.org/citations/2740350 | http://purl.uniprot.org/core/author | "Helman L.J."xsd:string |
| http://purl.uniprot.org/citations/2740350 | http://purl.uniprot.org/core/author | "Israel M.A."xsd:string |
| http://purl.uniprot.org/citations/2740350 | http://purl.uniprot.org/core/author | "Israel M.A."xsd:string |
| http://purl.uniprot.org/citations/2740350 | http://purl.uniprot.org/core/date | "1989"xsd:gYear |
| http://purl.uniprot.org/citations/2740350 | http://purl.uniprot.org/core/date | "1989"xsd:gYear |
| http://purl.uniprot.org/citations/2740350 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/2740350 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/2740350 | http://purl.uniprot.org/core/pages | "5178-5182"xsd:string |
| http://purl.uniprot.org/citations/2740350 | http://purl.uniprot.org/core/pages | "5178-5182"xsd:string |
| http://purl.uniprot.org/citations/2740350 | http://purl.uniprot.org/core/title | "Molecular cloning and primary structure of human glial fibrillary acidic protein."xsd:string |
| http://purl.uniprot.org/citations/2740350 | http://purl.uniprot.org/core/title | "Molecular cloning and primary structure of human glial fibrillary acidic protein."xsd:string |
| http://purl.uniprot.org/citations/2740350 | http://purl.uniprot.org/core/volume | "86"xsd:string |
| http://purl.uniprot.org/citations/2740350 | http://purl.uniprot.org/core/volume | "86"xsd:string |
| http://purl.uniprot.org/citations/2740350 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/2740350 |
| http://purl.uniprot.org/citations/2740350 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/2740350 |