| http://purl.uniprot.org/citations/27404388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27404388 | http://www.w3.org/2000/01/rdf-schema#comment | "Chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) is an orphan nuclear receptor that regulates many key biological processes, including organ development and cell fate determination. Although the biological functions of COUP-TFII have been studied extensively, little is known about what regulates its gene expression, especially the role of inducible extracellular factors in triggering it. Here we report that COUP-TFII expression is regulated specifically by fibroblast growth factor 2 (FGF2), which mediates activation of the MEK1/2 pathway in mesenchymal lineage C3H10T1/2 cells. Although FGF2 treatment increased cell proliferation, the induction of COUP-TFII expression was dispensable. Instead, FGF2-primed cells in which COUP-TFII expression was induced showed a low potential for osteoblast differentiation, as evidenced by decreases in alkaline phosphatase activity and osteogenic marker gene expression. Reducing COUP-TFII by U0126 or siRNA against COUP-TFII prevented the anti-osteogenic effect of FGF2, indicating that COUP-TFII plays a key role in the FGF2-mediated determination of osteoblast differentiation capability. This report is the first to suggest that FGF2 is an extracellular inducer of COUP-TFII expression and may suppress the osteogenic potential of mesenchymal cells by inducing COUP-TFII expression prior to the onset of osteogenic differentiation."xsd:string |
| http://purl.uniprot.org/citations/27404388 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0159234"xsd:string |
| http://purl.uniprot.org/citations/27404388 | http://purl.uniprot.org/core/author | "Kim J.W."xsd:string |
| http://purl.uniprot.org/citations/27404388 | http://purl.uniprot.org/core/author | "Hwang Y.C."xsd:string |
| http://purl.uniprot.org/citations/27404388 | http://purl.uniprot.org/core/author | "Jeong B.C."xsd:string |
| http://purl.uniprot.org/citations/27404388 | http://purl.uniprot.org/core/author | "Koh J.T."xsd:string |
| http://purl.uniprot.org/citations/27404388 | http://purl.uniprot.org/core/author | "Oh S.H."xsd:string |
| http://purl.uniprot.org/citations/27404388 | http://purl.uniprot.org/core/author | "Lee M.N."xsd:string |
| http://purl.uniprot.org/citations/27404388 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27404388 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/27404388 | http://purl.uniprot.org/core/pages | "e0159234"xsd:string |
| http://purl.uniprot.org/citations/27404388 | http://purl.uniprot.org/core/title | "FGF2 Stimulates COUP-TFII Expression via the MEK1/2 Pathway to Inhibit Osteoblast Differentiation in C3H10T1/2 Cells."xsd:string |
| http://purl.uniprot.org/citations/27404388 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/27404388 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27404388 |
| http://purl.uniprot.org/citations/27404388 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27404388 |
| http://purl.uniprot.org/uniprot/#_D3YYP4-mappedCitation-27404388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27404388 |
| http://purl.uniprot.org/uniprot/#_Q63932-mappedCitation-27404388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27404388 |
| http://purl.uniprot.org/uniprot/#_P15655-mappedCitation-27404388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27404388 |
| http://purl.uniprot.org/uniprot/#_P43135-mappedCitation-27404388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27404388 |
| http://purl.uniprot.org/uniprot/#_Q3UST6-mappedCitation-27404388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27404388 |
| http://purl.uniprot.org/uniprot/#_Q3USU3-mappedCitation-27404388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27404388 |
| http://purl.uniprot.org/uniprot/#_Q925A1-mappedCitation-27404388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27404388 |
| http://purl.uniprot.org/uniprot/#_Q925A2-mappedCitation-27404388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27404388 |
| http://purl.uniprot.org/uniprot/#_Q925A3-mappedCitation-27404388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27404388 |