| http://purl.uniprot.org/citations/27411010 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27411010 | http://www.w3.org/2000/01/rdf-schema#comment | "Non-nutritive sweeteners like sucralose are consumed by billions of people. While animal and human studies have demonstrated a link between synthetic sweetener consumption and metabolic dysregulation, the mechanisms responsible remain unknown. Here we use a diet supplemented with sucralose to investigate the long-term effects of sweet/energy imbalance. In flies, chronic sweet/energy imbalance promoted hyperactivity, insomnia, glucose intolerance, enhanced sweet taste perception, and a sustained increase in food and calories consumed, effects that are reversed upon sucralose removal. Mechanistically, this response was mapped to the ancient insulin, catecholamine, and NPF/NPY systems and the energy sensor AMPK, which together comprise a novel neuronal starvation response pathway. Interestingly, chronic sweet/energy imbalance promoted increased food intake in mammals as well, and this also occurs through an NPY-dependent mechanism. Together, our data show that chronic consumption of a sweet/energy imbalanced diet triggers a conserved neuronal fasting response and increases the motivation to eat."xsd:string |
| http://purl.uniprot.org/citations/27411010 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmet.2016.06.010"xsd:string |
| http://purl.uniprot.org/citations/27411010 | http://purl.uniprot.org/core/author | "Qi Y."xsd:string |
| http://purl.uniprot.org/citations/27411010 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/27411010 | http://purl.uniprot.org/core/author | "Neely G.G."xsd:string |
| http://purl.uniprot.org/citations/27411010 | http://purl.uniprot.org/core/author | "Penninger J.M."xsd:string |
| http://purl.uniprot.org/citations/27411010 | http://purl.uniprot.org/core/author | "Cole A.R."xsd:string |
| http://purl.uniprot.org/citations/27411010 | http://purl.uniprot.org/core/author | "Herzog H."xsd:string |
| http://purl.uniprot.org/citations/27411010 | http://purl.uniprot.org/core/author | "Wang Q.P."xsd:string |
| http://purl.uniprot.org/citations/27411010 | http://purl.uniprot.org/core/author | "Wong A.C."xsd:string |
| http://purl.uniprot.org/citations/27411010 | http://purl.uniprot.org/core/author | "Lin Y.Q."xsd:string |
| http://purl.uniprot.org/citations/27411010 | http://purl.uniprot.org/core/author | "Browman D.T."xsd:string |
| http://purl.uniprot.org/citations/27411010 | http://purl.uniprot.org/core/author | "Simpson S.J."xsd:string |
| http://purl.uniprot.org/citations/27411010 | http://purl.uniprot.org/core/author | "Khuong T.M."xsd:string |
| http://purl.uniprot.org/citations/27411010 | http://purl.uniprot.org/core/author | "Lau M.T."xsd:string |
| http://purl.uniprot.org/citations/27411010 | http://purl.uniprot.org/core/author | "Cotterell J."xsd:string |
| http://purl.uniprot.org/citations/27411010 | http://purl.uniprot.org/core/author | "Wilson Y.A."xsd:string |
| http://purl.uniprot.org/citations/27411010 | http://purl.uniprot.org/core/author | "Bakhshi N."xsd:string |
| http://purl.uniprot.org/citations/27411010 | http://purl.uniprot.org/core/author | "Cole T.A."xsd:string |
| http://purl.uniprot.org/citations/27411010 | http://purl.uniprot.org/core/author | "Oyston L.J."xsd:string |
| http://purl.uniprot.org/citations/27411010 | http://purl.uniprot.org/core/author | "Planchenault Y."xsd:string |
| http://purl.uniprot.org/citations/27411010 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27411010 | http://purl.uniprot.org/core/name | "Cell Metab"xsd:string |
| http://purl.uniprot.org/citations/27411010 | http://purl.uniprot.org/core/pages | "75-90"xsd:string |