| http://purl.uniprot.org/citations/27411635 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27411635 | http://www.w3.org/2000/01/rdf-schema#comment | "The mechanisms underlying haematopoietic lineage decisions remain disputed. Lineage-affiliated transcription factors with the capacity for lineage reprogramming, positive auto-regulation and mutual inhibition have been described as being expressed in uncommitted cell populations. This led to the assumption that lineage choice is cell-intrinsically initiated and determined by stochastic switches of randomly fluctuating cross-antagonistic transcription factors. However, this hypothesis was developed on the basis of RNA expression data from snapshot and/or population-averaged analyses. Alternative models of lineage choice therefore cannot be excluded. Here we use novel reporter mouse lines and live imaging for continuous single-cell long-term quantification of the transcription factors GATA1 and PU.1 (also known as SPI1). We analyse individual haematopoietic stem cells throughout differentiation into megakaryocytic-erythroid and granulocytic-monocytic lineages. The observed expression dynamics are incompatible with the assumption that stochastic switching between PU.1 and GATA1 precedes and initiates megakaryocytic-erythroid versus granulocytic-monocytic lineage decision-making. Rather, our findings suggest that these transcription factors are only executing and reinforcing lineage choice once made. These results challenge the current prevailing model of early myeloid lineage choice."xsd:string |
| http://purl.uniprot.org/citations/27411635 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature18320"xsd:string |
| http://purl.uniprot.org/citations/27411635 | http://purl.uniprot.org/core/author | "Burger A."xsd:string |
| http://purl.uniprot.org/citations/27411635 | http://purl.uniprot.org/core/author | "Ahmed N."xsd:string |
| http://purl.uniprot.org/citations/27411635 | http://purl.uniprot.org/core/author | "Burtscher I."xsd:string |
| http://purl.uniprot.org/citations/27411635 | http://purl.uniprot.org/core/author | "Lickert H."xsd:string |
| http://purl.uniprot.org/citations/27411635 | http://purl.uniprot.org/core/author | "Theis F.J."xsd:string |
| http://purl.uniprot.org/citations/27411635 | http://purl.uniprot.org/core/author | "Gambardella A."xsd:string |
| http://purl.uniprot.org/citations/27411635 | http://purl.uniprot.org/core/author | "Rieger M.A."xsd:string |
| http://purl.uniprot.org/citations/27411635 | http://purl.uniprot.org/core/author | "Coutu D.L."xsd:string |
| http://purl.uniprot.org/citations/27411635 | http://purl.uniprot.org/core/author | "Schroeder T."xsd:string |
| http://purl.uniprot.org/citations/27411635 | http://purl.uniprot.org/core/author | "Nerlov C."xsd:string |
| http://purl.uniprot.org/citations/27411635 | http://purl.uniprot.org/core/author | "Ermakova O."xsd:string |
| http://purl.uniprot.org/citations/27411635 | http://purl.uniprot.org/core/author | "Loeffler D."xsd:string |
| http://purl.uniprot.org/citations/27411635 | http://purl.uniprot.org/core/author | "Marr C."xsd:string |
| http://purl.uniprot.org/citations/27411635 | http://purl.uniprot.org/core/author | "Moritz N."xsd:string |
| http://purl.uniprot.org/citations/27411635 | http://purl.uniprot.org/core/author | "Etzrodt M."xsd:string |
| http://purl.uniprot.org/citations/27411635 | http://purl.uniprot.org/core/author | "Endele M."xsd:string |
| http://purl.uniprot.org/citations/27411635 | http://purl.uniprot.org/core/author | "Hoppe P.S."xsd:string |
| http://purl.uniprot.org/citations/27411635 | http://purl.uniprot.org/core/author | "Kokkaliaris K.D."xsd:string |
| http://purl.uniprot.org/citations/27411635 | http://purl.uniprot.org/core/author | "Schwarzfischer M."xsd:string |
| http://purl.uniprot.org/citations/27411635 | http://purl.uniprot.org/core/author | "Filipczyk A."xsd:string |
| http://purl.uniprot.org/citations/27411635 | http://purl.uniprot.org/core/author | "Hilsenbeck O."xsd:string |
| http://purl.uniprot.org/citations/27411635 | http://purl.uniprot.org/core/author | "Schauberger B."xsd:string |