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| http://purl.uniprot.org/citations/27416754 | http://www.w3.org/2000/01/rdf-schema#comment | "Tetraspanin family proteins regulate morphology, motility, fusion, and signaling in various cell types. We investigated the role of the tetraspanin 7 (Tspan7) isoform in the differentiation and function of osteoclasts. Tspan7 was up-regulated during osteoclastogenesis. When Tspan7 expression was reduced in primary precursor cells by siRNA-mediated gene knock-down, the generation of multinuclear osteoclasts was not affected. However, a striking cytoskeletal abnormality was observed: the formation of the podosome belt structure was inhibited and the microtubular network were disrupted by Tspan7 knock-down. Decreases in acetylated microtubules and levels of phosphorylated Src and Pyk2 in Tspan7 knock-down cells supported the involvement of Tspan7 in cytoskeletal rearrangement signaling in osteoclasts. This cytoskeletal defect interfered with sealing zone formation and subsequently the bone-resorbing activity of mature osteoclasts on dentin surfaces. Our results suggest that Tspan7 plays an important role in cytoskeletal organization required for the bone-resorbing function of osteoclasts by regulating signaling to Src, Pyk2, and microtubules."xsd:string |
| http://purl.uniprot.org/citations/27416754 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2016.07.046"xsd:string |
| http://purl.uniprot.org/citations/27416754 | http://purl.uniprot.org/core/author | "Kim H."xsd:string |
| http://purl.uniprot.org/citations/27416754 | http://purl.uniprot.org/core/author | "Kim M.K."xsd:string |
| http://purl.uniprot.org/citations/27416754 | http://purl.uniprot.org/core/author | "Lee Z.H."xsd:string |
| http://purl.uniprot.org/citations/27416754 | http://purl.uniprot.org/core/author | "Kim H.H."xsd:string |
| http://purl.uniprot.org/citations/27416754 | http://purl.uniprot.org/core/author | "Lee Y.D."xsd:string |
| http://purl.uniprot.org/citations/27416754 | http://purl.uniprot.org/core/author | "Song M.K."xsd:string |
| http://purl.uniprot.org/citations/27416754 | http://purl.uniprot.org/core/author | "Kwon J.O."xsd:string |
| http://purl.uniprot.org/citations/27416754 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27416754 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/27416754 | http://purl.uniprot.org/core/pages | "1078-1084"xsd:string |
| http://purl.uniprot.org/citations/27416754 | http://purl.uniprot.org/core/title | "Tetraspanin 7 regulates sealing zone formation and the bone-resorbing activity of osteoclasts."xsd:string |
| http://purl.uniprot.org/citations/27416754 | http://purl.uniprot.org/core/volume | "477"xsd:string |
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